暴露于慢性低水平铅环境下的小鼠T细胞功能下降。
Decreased T cell function in mice exposed to chronic, low levels of lead.
作者信息
Neilan B A, Taddeini L, McJilton C E, Handwerger B S
出版信息
Clin Exp Immunol. 1980 Mar;39(3):746-9.
The immune responsiveness of mice given low levels of lead acetate (1300 p.p.m.) in their drinking water for 8 weeks was determined. Mean percentages of splenic T and B lymphocytes in lead-exposed mice were slightly lower than in controls. Mean mitogen response to phytohaemmaglutinin and concanavalin A in mice exposed to lead was significantly decreased compared to controls. The response to lipopolysaccharide on the other hand was not significantly mitogenic response to phytohaemagglutinin and concanavalin A is impaired in mice exposed chronically to low concentrations of lead.
测定了给小鼠饮用含低水平醋酸铅（1300 ppm）的水8周后的免疫反应性。铅暴露小鼠脾脏T淋巴细胞和B淋巴细胞的平均百分比略低于对照组。与对照组相比，铅暴露小鼠对植物血凝素和刀豆球蛋白A的平均有丝分裂原反应显著降低。另一方面，对脂多糖的反应与对照组相比无显著差异。长期暴露于低浓度铅的小鼠对植物血凝素和刀豆球蛋白A的有丝分裂原反应受损。
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