三种局部用驱虫剂在犬和兔中的皮肤渗透情况。

Dermal penetration of three topical insect repellents in dogs and rabbits.

作者信息

Snodgrass H L, Weeks M H

出版信息

Am Ind Hyg Assoc J. 1978 Jul;39(7):540-5. doi: 10.1080/0002889778507806.

Abstract

Three (14)C-labeled candidate insect repellents, cyclohexamethylene carbamide, n-butylsufonimidocyclohexamethylene and 2-hydroxyethylcyclohexane carboxylate were evaluated for skin penetration in dogs and rabbits. Absorption of the repellents was determined by monitoring excreted urine daily for seven days following topical application. Significant percutaneous absorption of all three repellents occurred within 24 hours. (14)C-cyclohexamethylene carbamide showed the greatest absorption. Measurable amounts of radioactivity persisted at the application site for both species after seven days.

摘要

对三种用¹⁴C标记的候选驱虫剂——环己亚甲基碳酰胺、正丁基磺酰亚胺基环己亚甲基和2-羟乙基环己烷羧酸酯，进行了犬和兔皮肤渗透评估。在局部应用后，通过连续七天每日监测排泄尿液来测定驱虫剂的吸收情况。所有三种驱虫剂在24小时内均出现显著的经皮吸收。¹⁴C-环己亚甲基碳酰胺的吸收量最大。七天后，两种动物的应用部位均残留有可测量的放射性。