Church J A, Uittenbogaart C
Ann Allergy. 1980 Apr;44(4):212-6.
A three-month-old girl with congenital immune deficiency developed graft-versus-host disease following engraftment of maternal immunocompetent cells. T and B lymphocyte numbers increased and lymphocyte responsiveness to phytohemagglutinin normalized during the patient's hospitalization. However, these cells failed to respond to pokeweed mitogen and several specific antigens, suggesting that the expanding clone of alloreactive cells had limited immunologic potential. Serum IgE concentration rose from an undetectable level to 2,600 u/ml, indicating an immunoregulatory imbalance. HLA typing revealed that the patient's parents shared HLA antigen specificities. Finally, experimental administration of antithymocyte globulin had no beneficial effect upon the patient's clinical course or laboratory findings.
一名患有先天性免疫缺陷的三个月大女童在植入母体免疫活性细胞后发生了移植物抗宿主病。在患者住院期间，T和B淋巴细胞数量增加，淋巴细胞对植物血凝素的反应性恢复正常。然而，这些细胞对商陆有丝分裂原和几种特异性抗原无反应，提示同种反应性细胞的扩增克隆具有有限的免疫潜能。血清IgE浓度从不可检测水平升至2600 u/ml，表明存在免疫调节失衡。HLA分型显示患者父母共享HLA抗原特异性。最后，实验性给予抗胸腺细胞球蛋白对患者的临床病程或实验室检查结果无有益影响。
