人甲胎蛋白（HAFP）对人淋巴细胞转化的抑制作用；HAFP单体、多聚体及抗性淋巴细胞亚群

Inhibition of human lymphocyte transformation by human alpha-fetoprotein (HAFP); HAFP monomers and multimers and a resistant lymphocyte subpopulation.

作者信息

Yachnin S, Lester E P

出版信息

J Immunol. 1977 Aug;119(2):555-7.

PMID:69662

Abstract

We have previously shown that human alpha-fetoprotein (HAFP) inhibits the response in vitro of human lymphocytes to a variety of mitogenic stimuli. In this report we present evidence that HAFP preparations containing dimeric and trimeric forms are no more inhibitory than HAFP monomeric isolates. HAFP isolates of low inhibitory potency cannot impede the capacity of high-potency HAFP to inhibit lymphocyte transformation. Since lymphocyte responses to phytomitogens or anti-human thymocyte antiserum cannot be totally suppressed by increasing doses of HAFP, we conclude that human lymphocyte preparations contain a population of lymphocytes resistant to the inhibitory action of HAFP.

摘要

我们之前已经表明，人甲胎蛋白（HAFP）在体外可抑制人淋巴细胞对多种促有丝分裂刺激的反应。在本报告中，我们提供证据表明，含有二聚体和三聚体形式的HAFP制剂的抑制作用并不比HAFP单体分离物更强。低抑制效力的HAFP分离物无法阻碍高效力HAFP抑制淋巴细胞转化的能力。由于增加HAFP剂量并不能完全抑制淋巴细胞对植物促细胞分裂剂或抗人胸腺细胞抗血清的反应，我们得出结论，人淋巴细胞制剂中含有一群对HAFP的抑制作用具有抗性的淋巴细胞。

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Inhibition of human lymphocyte transformation by human alpha-fetoprotein (HAFP); HAFP monomers and multimers and a resistant lymphocyte subpopulation.人甲胎蛋白（HAFP）对人淋巴细胞转化的抑制作用；HAFP单体、多聚体及抗性淋巴细胞亚群

J Immunol. 1977 Aug;119(2):555-7.

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J Natl Cancer Inst. 1981 Apr;66(4):625-30.

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