Hemodynamic effects of an intravenous injection of mexiletine in patients hospitalised in intensive care units.

Hemodynamic effects of mexiletine were studied in 15 patients with normal sinus rhythm; most of them had a myocardial infarction. Except for a slight increase in peripheral vascular resistance, no other significant change in hemodynamic parameters was found after an intravenous injection of 1.5 mg/kg of mexiletine at 25 mg/min.