[Hemodynamic effects of lidocaine and mexiletine in acute heart infarction].

The effect of lidocaine (1.0 mg/kg body weight) and mexiletine (1.5 mg/kg body weight) on the arterial blood pressure, the pulmonary artery pressure, heart rate and relative stroke volume were investigated in 9 patients with acute myocardial infarction. The medicaments given as intravenous bolus did not influence significantly the arithmetical mean values of blood pressure, heart rate, pulmonary artery pressure and relative stroke volume. In two cases, however, the application of mexiletine resulted in a strong increase of the pulmonary artery pressure. In one case both drugs caused a significant decrease of the stroke volume.