Reinertsen J L, Kaslow R A, Klippel J H, Hurvitz A I, Lewis R M, Rothfield N F, Zvaifler N J, Steinberg A D, Decker J L
Arthritis Rheum. 1980 May;23(5):564-8. doi: 10.1002/art.1780230507.
To determine whether exposure to canine lupus is a risk for human lupus, we studied 83 members of 23 households exposed to 19 dogs with high titer antinuclear antibodies and compared these contact households to 50 members of 18 control households matched for dog age, sex, and primary veterinarian. No differences were found between contacts and controls in titer of antinuclear, antiDNA, antiRNA, and antilymphocyte antibodies, frequency of positive rheumatoid factor, or elevated serum immunoglobulins. Further analysis of subgroups by age, sex, and intensity of dog exposure did not reveal any serologic differences between contacts and controls. No cases of lupus were identified in either group. Three contact households and no controls reported a family history (remote from the household) of lupus. This study did not detect any clinical or serologic effect of human household exposure to dogs with high titer antinuclear antibodies.
为了确定接触患狼疮的犬类是否会使人患狼疮，我们研究了23户家庭中的83名成员，这些家庭接触了19只抗核抗体效价高的犬，并将这些接触组家庭与18户对照家庭中的50名成员进行比较，对照家庭的犬在年龄、性别和主治兽医方面相匹配。在抗核抗体、抗DNA抗体、抗RNA抗体和抗淋巴细胞抗体的效价、类风湿因子阳性频率或血清免疫球蛋白升高方面，接触组和对照组之间未发现差异。按年龄、性别和接触犬的强度对亚组进行的进一步分析未显示接触组和对照组之间存在任何血清学差异。两组均未发现狼疮病例。三个接触组家庭报告有狼疮家族史（与家庭关系较远），而对照组家庭均未报告。本研究未检测到人类家庭接触抗核抗体效价高的犬类产生的任何临床或血清学影响。
