Patel K D, Dalal F Y
Can Anaesth Soc J. 1980 May;27(3):260-3. doi: 10.1007/BF03007437.
Carcinoid tumors with hepatic involvement can produce intense flushing, tachycardia, hypotension or hypertension and diarrhoea. Patients with limited cardiac reserve may not tolerate these effects under anaesthesia. Valvular heart disease associated with carcinoid tumors has been reported, but there is no record in the literature of such an association with coronary artery disease. This report presents the anaesthetic management of a patient with coronary artery disease and carcinoid tumor undergoing myocardial revascularization. Emphasis is placed on the rational use of anaesthetic and adjunctive agents which will minimize the incidence of carcinoid symptons. The salient features of the management are prevention of release of vasoactive substances by the use of promethazine hydrochloride during operation, the avoidance of stropine, prophylactic administration of corticosteroids and smooth induction of anaesthesia by the use of diazepam and dimethyl-tubocurarine iodide (Metocurine).
伴有肝脏受累的类癌肿瘤可引起强烈潮红、心动过速、低血压或高血压以及腹泻。心脏储备功能有限的患者在麻醉状态下可能无法耐受这些影响。有报道称类癌肿瘤与瓣膜性心脏病有关,但文献中没有关于此类肿瘤与冠状动脉疾病关联的记录。本报告介绍了一名患有冠状动脉疾病和类癌肿瘤的患者在进行心肌血运重建时的麻醉管理。重点在于合理使用麻醉剂和辅助药物,以尽量减少类癌症状的发生率。管理的显著特点包括在手术期间使用盐酸异丙嗪防止血管活性物质释放、避免使用阿托品、预防性给予皮质类固醇以及使用地西泮和碘化二甲基筒箭毒碱(美卡咪脲)平稳诱导麻醉。