Giulling E V, Nikol'skiĭ I S, Diugovskaia L A, Chernenko O D, Ovsienko V V
Biull Eksp Biol Med. 1980 May;89(5):584-5.
Mastocytes of newborn rats as well as those of adult ones are capable of rosette-formation, whereas the ability of lymphocytes to from rosettes increases with age. The thymocytes of 3-month-old mice lose the ability to mastolymphocytic rosette-formation (MLR) after priming for one hour at 45 degrees C. The ability of thymocytes and splenocytes to MLR-formation is closely related to the time course of immunization of the animals and the method of immunization. The thymocytes and splenocytes of mice with leukemia show a decreased and increased ability to MLR-formation, respectively.
新生大鼠的肥大细胞以及成年大鼠的肥大细胞都能够形成玫瑰花结，而淋巴细胞形成玫瑰花结的能力则随年龄增长而增强。3月龄小鼠的胸腺细胞在45℃预处理1小时后丧失了形成肥大淋巴细胞玫瑰花结（MLR）的能力。胸腺细胞和脾细胞形成MLR的能力与动物免疫的时间进程和免疫方法密切相关。患白血病小鼠的胸腺细胞和脾细胞形成MLR的能力分别降低和增强。
