[Detection of a specific differentiation antigen of mouse T-cells activated by allogenic transplantation antigens].

Xenogeneic antibody was obtained, which displayed cytotoxicity for T lymphocytes in mice belonging to varied inbred strains activated with allogeneic cells. This antibody was not cytotoxic for nonactivated T or B lymphocytes of intact mice. Absorption of antiserum with activated rather than with intact lymphocytes diminished its cytotoxicity. Both activated and nonactivated lymphocytes were found to be equally susceptible to the cytotoxic effect of antilymphocytic or antithymocytic sera. A conclusion is made that murine T lymphocytes activated with allogeneic transplantation antigen carry specific differentiation antigen.