Shiosaka S, Tohyama M, Takagi H, Takahashi Y, Saitoh Y, Sakumoto T, Nakagawa H, Shimizu N
Exp Brain Res. 1980;39(4):377-88. doi: 10.1007/BF00239302.
The ascending and descending components of the medial forebrain bundle (MFB) were investigated by means of horseradish peroxidase (HRP) with a sensitive substrate. The HRP was injected iontophoretically into the MFB at various levels from the anterior commissure to the posterior hypothalamus. In order to prevent the diffusion of HRP to other brain areas, a double micropipette system was used. The descending components of the MFB are derived from (1) the anterior cingulate area, infra- or prelimbic area, and sulcal cortex, (2) the lateral septal nucleus and diagonal band, (3) the bed nucleus of the stria terminalis, (4) the paraventricular nucleus (5) the substantia innominata, (6) the amygdaloid complex (AM), (7) the ventromedial (VM) and dorsomedial (DM) hypothalamic nuclei, (8) the entopeduncular nucleus and (9) nucleus periventricularis stellatocellularis. The ascending components of the MFB originate in: (1) the medial preoptic nucleus, (2) the nucleus periventricularis stellatocellularis and rotundocellularis, (3) the posterior hypothalamic nucleus, (4) the parafascicular nucleus, (5) the ventral premammillary nucleus, (6) the substantia grisea periventricularis, (7) the lateral habenular nucleus, (8) the VM and DM, (9) the paratenial nucleus, (10) the AM and (11) the arcuate nucleus.
采用辣根过氧化物酶（HRP）和一种敏感底物，对内侧前脑束（MFB）的升支和降支进行了研究。将HRP通过离子电泳法注入从前连合到下丘脑后部不同水平的MFB中。为防止HRP扩散到其他脑区，使用了双微管系统。MFB的降支源自：（1）前扣带区、嗅下或嗅前区以及沟回皮质；（2）外侧隔核和斜角带；（3）终纹床核；（4）室旁核；（5）无名质；（6）杏仁复合体（AM）；（7）下丘脑腹内侧核（VM）和背内侧核（DM）；（8）内囊旁核；（9）室周星状细胞核。MFB的升支起源于：（1）内侧视前核；（2）室周星状细胞核和圆形细胞核；（3）下丘脑后核；（4）束旁核；（5）腹侧乳头前核；（6）室周灰质；（7）外侧缰核；（8）VM和DM；（9）旁中央核；（10）AM；（11）弓状核。
