Hahn Joel D, Swanson Larry W
Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-2520, USA.
Brain Res Rev. 2010 Sep;64(1):14-103. doi: 10.1016/j.brainresrev.2010.02.002. Epub 2010 Feb 17.
We have analyzed at high resolution the neuroanatomical connections of the juxtaparaventricular region of the lateral hypothalamic area (LHAjp); as a control and in comparison to this, we also performed a preliminary analysis of a nearby LHA region that is dorsal to the fornix, namely the LHA suprafornical region (LHAs). The connections of these LHA regions were revealed with a coinjection tract-tracing technique involving a retrograde (cholera toxin B subunit) and anterograde (Phaseolus vulgaris leucoagglutinin) tracer. The LHAjp and LHAs together connect with almost every major division of the cerebrum and cerebrospinal trunk, but their connection profiles are markedly different and distinct. In simple terms, the connections of the LHAjp indicate a possible primary role in the modulation of defensive behavior; for the LHAs, a role in the modulation of ingestive behavior is suggested. However, the relation of the LHAjp and LHAs to potential modulation of these behaviors, as indicated by their neuroanatomical connections, appears to be highly integrative as it includes each of the major functional divisions of the nervous system that together determine behavior, i.e., cognitive, state, sensory, and motor. Furthermore, although a primary role is indicated for each region with respect to a particular mode of behavior, intermode modulation of behavior is also indicated. In summary, the extrinsic connections of the LHAjp and LHAs (so far as we have described them) suggest that these regions have a profoundly integrative role in which they may participate in the orchestrated modulation of elaborate behavioral repertoires.
我们以高分辨率分析了下丘脑外侧区室旁区域（LHAjp）的神经解剖连接；作为对照并与之相比，我们还对穹窿背侧附近的下丘脑外侧区区域，即穹窿上区域（LHAs）进行了初步分析。这些下丘脑外侧区区域的连接通过一种联合注射示踪技术得以揭示，该技术涉及逆行示踪剂（霍乱毒素B亚基）和顺行示踪剂（菜豆白细胞凝集素）。LHAjp和LHAs共同与大脑和脑脊髓干的几乎每个主要部分相连，但它们的连接模式明显不同且有区别。简单来说，LHAjp的连接表明其在防御行为调节中可能起主要作用；对于LHAs，则提示其在摄食行为调节中发挥作用。然而，LHAjp和LHAs与这些行为潜在调节之间的关系，正如其神经解剖连接所示，似乎具有高度整合性，因为它包括了共同决定行为的神经系统的每个主要功能部分，即认知、状态、感觉和运动部分。此外，尽管每个区域在特定行为模式方面显示出主要作用，但也表明了行为的模式间调节。总之，LHAjp和LHAs的外在连接（就我们目前所描述的而言）表明，这些区域具有深刻的整合作用，它们可能参与精心编排的行为模式的协调调节。
