牙买加高血压患者药物诱导免疫变化的患病率
Prevalence of drug-induced immunologic changes in hypertensive Jamaicans.
作者信息
Grell G A, Wilson W A, James O
出版信息
South Med J. 1980 Aug;73(8):1044-5. doi: 10.1097/00007611-198008000-00026.
Abstract
Of 137 hypertensive black Jamaicans who took methyldopa for a mean period of 36 months, a positive ANA was found in 1.5% and a positive direct Coombs' test in 0.7%. In 36 patients in whom hydralazine was included in the therapeutic regimen, a positive ANA was seen in only 6%. These results suggest that in black populations, immunologic abnormalities induced by antihypertensive drugs are less common than has been reported in white patients.
摘要
在137名平均服用甲基多巴36个月的牙买加黑人高血压患者中，抗核抗体阳性率为1.5%，直接抗人球蛋白试验阳性率为0.7%。在治疗方案中包含肼屈嗪的36名患者中，抗核抗体阳性率仅为6%。这些结果表明，在黑人人群中，降压药引起的免疫异常比在白人患者中报道的要少见。
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