接受非心得宁β受体阻滞剂治疗患者的抗核抗体
Antinuclear antibodies in patients receiving non-practolol beta-blockers.
作者信息
Wilson J D, Bullock J Y, Sutherland D C, Main C, O'Brien K P
出版信息
Br Med J. 1978 Jan 7;1(6104):14-6. doi: 10.1136/bmj.1.6104.14.
Abstract
Antinuclear antibodies (ANA) were found in 54 (7.0%) out of 767 treated hypertensive patients compared with 59 (2.4%) out of 2470 healthy controls. Inclusion of a non-practolol beta-blocker in the treatment regimen did not significantly affect the incidence of ANA. ANA was found in significantly more patients being treated with methyldopa (13.0%) than patients receiving other hypotensive agents (3.8%). Non-practolol beta-blockers in combination with methyldopa did not increase the incidence of ANA further.
摘要
在767例接受治疗的高血压患者中，发现54例（7.0%）存在抗核抗体（ANA），而在2470例健康对照者中，这一比例为59例（2.4%）。治疗方案中加入非心得安β受体阻滞剂对ANA的发生率没有显著影响。接受甲基多巴治疗的患者中ANA的检出率（13.0%）显著高于接受其他降压药物治疗的患者（3.8%）。非心得安β受体阻滞剂与甲基多巴联合使用并未进一步增加ANA的发生率。
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2
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