Constancy of pharmacokinetic properties of the lymphocyte insulin receptor during aging.
作者信息
Helderman J H
出版信息
J Gerontol. 1980 May;35(3):329-34. doi: 10.1093/geronj/35.3.329.
PMID:6967884
Abstract
Carbohydrate metabolism is altered during aging. Alterations at the pancreatic beta cell and at the level of peripheral sensitivity to insulin have been invoked. The T lymphocyte insulin receptor from five younger and five older men were studied. Pharmacokinetic characteristics (affinity, kd, and receptor sites per cell) were the same for both. Peripheral insensitivity at the level of the hormone receptor does not explain the altered metabolism.
摘要
相似文献
1
Constancy of pharmacokinetic properties of the lymphocyte insulin receptor during aging.
J Gerontol. 1980 May;35(3):329-34. doi: 10.1093/geronj/35.3.329.
2
Acute regulation of human lymphocyte insulin receptors. Analysis by the glucose clamp.人淋巴细胞胰岛素受体的急性调节。通过葡萄糖钳夹技术进行分析。
J Clin Invest. 1984 Oct;74(4):1428-35. doi: 10.1172/JCI111554.
3
Insulin-induced desensitization at the receptor and postreceptor level in mitogen-activated human T-lymphocytes.胰岛素诱导的有丝分裂原激活的人T淋巴细胞中受体及受体后水平的脱敏作用。
Diabetes. 1985 Sep;34(9):931-7. doi: 10.2337/diab.34.9.931.
4
Tunicamycin blocks the emergence and maintenance of insulin receptors on mitogen-activated human T lymphocytes.衣霉素可阻断有丝分裂原激活的人T淋巴细胞上胰岛素受体的出现和维持。
Metabolism. 1984 Apr;33(4):309-16. doi: 10.1016/0026-0495(84)90189-6.
5
The T lymphocyte insulin receptor in diabetes and obesity: an intrinsic binding defect.糖尿病和肥胖症中的T淋巴细胞胰岛素受体：一种内在结合缺陷
Diabetes. 1980 Jul;29(7):551-7. doi: 10.2337/diab.29.7.551.
6
Age-related changes in the formation of glucocorticoid and insulin receptors during lectin-induced activation of human peripheral blood lymphocytes.凝集素诱导人外周血淋巴细胞活化过程中糖皮质激素和胰岛素受体形成的年龄相关变化。
Gerontology. 1985;31(5):293-300. doi: 10.1159/000212712.
7
In vitro control of T-lymphocyte insulin receptors by in vivo modulation of insulin.通过体内胰岛素调节对T淋巴细胞胰岛素受体进行体外控制
Diabetes. 1983 Aug;32(8):712-7. doi: 10.2337/diab.32.8.712.
8
Expression of glucagon receptors on T- and B- lymphoblasts: comparison with insulin receptors.胰高血糖素受体在T淋巴细胞和B淋巴细胞母细胞上的表达：与胰岛素受体的比较。
Endocrinology. 1982 Aug;111(2):684-92. doi: 10.1210/endo-111-2-684.
9
Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation.人外周血单个核细胞中1,25 - 二羟维生素D3的特异性高亲和力受体：存在于单核细胞中，并在T淋巴细胞激活后诱导产生。
J Clin Endocrinol Metab. 1983 Dec;57(6):1308-10. doi: 10.1210/jcem-57-6-1308.
10
The role of insulin in the response of murine T lymphocytes to mitogenic stimulation in vitro.胰岛素在体外小鼠T淋巴细胞对有丝分裂原刺激反应中的作用。
J Immunol. 1980 Feb;124(2):739-44.
引用本文的文献
1
Characterization of the insulin resistance of aging.衰老过程中胰岛素抵抗的特征描述。
J Clin Invest. 1983 Jun;71(6):1581-7. doi: 10.1172/jci110914.
Zotero 插件