HECA-452在副银屑病和蕈样肉芽肿中的表达。

Expression of HECA-452 in parapsoriasis and mycosis fungoides.

作者信息

Di Trolio R, Di Lorenzo G, Barbiero E, Iacono A, Franco R, D Armiento M, Delfino M, D Armiento F P

机构信息

Dipartimento di Patologia Sistematica-Clinica Dermatologica, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131 Naples, Italy.

出版信息

Int J Immunopathol Pharmacol. 2006 Jan-Mar;19(1):105-10.

PMID:16569348

Abstract

We have investigated the HECA-452 expression in large plaque parapsoriasis (PP) and mycosis fungoides (MF) patients, evaluating the potential role of this biomarker in both cutaneous disorders. Skin specimens from 72 PP and 61 MF patients were selected in this study. We compared their actual histological diagnosis with their previous diagnosis and we found that all 72 PP patients had the same diagnosis as before (stable PP), while 26 out of 61 MF had a previous PP histological diagnosis (evolving PP). Our results show an increased expression of HECA-452 in MF compared to PP (p<0.01). Furthermore, evolving PP showed a significantly higher level of HECA-452 than stable PP (p<0.05). We conclude that HECA-452 expression increases during the natural history of Mycosis Fungoides. HECA-452 could be used as a biomarker for MF and predict which PP evolves to MF.

摘要

我们研究了大斑块状副银屑病（PP）和蕈样肉芽肿（MF）患者的HECA-452表达情况，评估了该生物标志物在这两种皮肤疾病中的潜在作用。本研究选取了72例PP患者和61例MF患者的皮肤标本。我们将他们实际的组织学诊断与其先前的诊断进行了比较，发现所有72例PP患者的诊断与之前相同（稳定型PP），而61例MF患者中有26例先前的组织学诊断为PP（进展型PP）。我们的结果显示，与PP相比，MF中HECA-452的表达增加（p<0.01）。此外，进展型PP的HECA-452水平显著高于稳定型PP（p<0.05）。我们得出结论，在蕈样肉芽肿的自然病程中，HECA-452表达增加。HECA-452可作为MF的生物标志物，并预测哪些PP会进展为MF。