同种反应性且受H-2限制的Lyt 23细胞毒性T淋巴细胞源自共同的前体Lyt 123前体细胞库。
Alloreactive and H-2-restricted Lyt 23 cytotoxic T lymphocytes derive from a common pool of antecedent Lyt 123 precursors.
作者信息
Hardt C, Pfizenmaier K, Röllinghoff M, Klein J, Wagner H
出版信息
J Exp Med. 1980 Nov 1;152(5):1413-8. doi: 10.1084/jem.152.5.1413.
Abstract
If the collaborative requirement of Lyt 1 T helper cells is bypassed by the Lyt 1 T cell-derived mediator of T help, termed Il-2, upon antigenic stimulation, PNA+ Lyt 123 thymocytes differentiate into either alloreactive or H-2-restricted PNA- Lyt 23 cytotoxic effector cells. Along the differentiation pathway from Lyt 123 leads to 23 effector cells, cytolytic activity is carried out by T cells that still express the Lyt 123 phenotype. The data establish that Lyt 23 CTL are produced by differentiation from antecedent Lyt 123 cells.
摘要
如果在抗原刺激时，由Lyt 1 T细胞衍生的T辅助因子（称为Il-2）绕过Lyt 1辅助性T细胞的协同需求，PNA + Lyt 123胸腺细胞就会分化为同种异体反应性或H-2限制性的PNA - Lyt 23细胞毒性效应细胞。在从Lyt 123细胞到23效应细胞的分化途径中，细胞溶解活性由仍表达Lyt 123表型的T细胞执行。这些数据证实，Lyt 23细胞毒性T淋巴细胞是由先前的Lyt 123细胞分化产生的。
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Alloreactive and H-2-restricted Lyt 23 cytotoxic T lymphocytes derive from a common pool of antecedent Lyt 123 precursors.同种反应性且受H-2限制的Lyt 23细胞毒性T淋巴细胞源自共同的前体Lyt 123前体细胞库。
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2
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Cell-mediated cytotoxicity to trinitrophenyl-modified syngeneic lymphocytes.对三硝基苯基修饰的同基因淋巴细胞的细胞介导细胞毒性。
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J Exp Med. 1978 Dec 1;148(6):1523-38. doi: 10.1084/jem.148.6.1523.
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