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正常小鼠的T细胞促进辐射诱导淋巴瘤的生长。

Enhancement of growth of a radiation-induced lymphoma by T cells from normal mice.

作者信息

Gabizon A, Trainin N

出版信息

Br J Cancer. 1980 Oct;42(4):551-8. doi: 10.1038/bjc.1980.279.

DOI:10.1038/bjc.1980.279
PMID:6969087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2010444/
Abstract

The effect of lymphocytes from normal mice on the growth of a syngeneic, radiation-induced, T-cell-derived lymphoma was investigated. Thymus and spleen cells enhanced the growth of admixed lymphoma cells in a reproducible manner. Growth enhancement was manifested by the earlier appearance and higher final incidence of tumours. Lymphocytes also enhanced the growth of radiation-damaged lymphoma cells. The enhancing activity of spleen cells was predominantly a property of T cells, since it was abolished by treatment with anti-theta serum plus complement and significantly less in spleen cells of nude mice. Tumour-enhancing thymocytes seem to belong to the immature thymic subpopulation, as indicated by their binding to peanut agglutinin.

摘要

研究了正常小鼠淋巴细胞对同基因、辐射诱导的T细胞源性淋巴瘤生长的影响。胸腺细胞和脾细胞以可重复的方式促进了混合淋巴瘤细胞的生长。生长促进表现为肿瘤出现更早且最终发病率更高。淋巴细胞还促进了受辐射损伤的淋巴瘤细胞的生长。脾细胞的增强活性主要是T细胞的特性，因为用抗θ血清加补体处理可消除该活性，且裸鼠脾细胞中的活性明显较低。肿瘤增强性胸腺细胞似乎属于未成熟胸腺亚群，这可通过它们与花生凝集素的结合来表明。

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本文引用的文献

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Immune mechanisms in homotransplantation. II. Quantitative assay of the immunologic activity of lymphoid cells stimulated by tumor homografts.同种移植中的免疫机制。II. 肿瘤同种移植物刺激的淋巴细胞免疫活性的定量测定。
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