5-羟色胺的突触前作用及嘌呤能神经支配参与家兔下尿路的证据。
Evidence for the presynaptic action of 5-hydroxytryptamine and the involvement of purinergic innervation in the rabbit lower urinary tract.
作者信息
Chen H I
机构信息
University Department of Pharmacology, University of Oxford.
出版信息
Br J Pharmacol. 1990 Sep;101(1):212-6. doi: 10.1111/j.1476-5381.1990.tb12115.x.
Abstract
- The effects of 5-hydroxytryptamine (5-HT) were studied in vitro on bladder and urethral muscle strips from the rabbit. 5-HT produced dose-dependent contraction in the detrusor and urethra. 2. The 5-HT-induced contraction could be dose-dependently inhibited by the 5-HT3 antagonists MDL 72222, ICS 205-930 and BRL 43694. No effect of ketanserin, methysergide or metitepine was observed on the contractile response to 5-HT. 3. Atropine and alpha, beta-methylene ATP both partially blocked the contractile response to 5-HT. Together they caused more inhibition than either alone. 4. Atropine and alpha, beta-methylene ATP also inhibited the contractile response to electrical field stimulation. The 5-HT3 antagonist MDL 72222 had no effect on the contraction to field stimulation. 5. The atropine- and alpha, beta-methylene ATP-resistant components of 5-HT-induced contraction were not affected by the 5-HT1 antagonists metitepine, the 5-HT2 antagonists ketanserin and methysergide or the 5-HT3 antagonists MDL 72222, ICS 205-930 and BRL 43694. 6. Tetrodotoxin, hexamethonium, phentolamine and prazosin had no effect on the contractile response to 5-HT. 7. These results suggest that in the rabbit lower urinary tract (i) there are 5-HT3 receptors, (ii) the contractile response to 5-HT is mediated by presynaptic stimulation, (iii) there is non-adrenergic, non-cholinergic excitatory neurotransmission.
摘要
在体外研究了5-羟色胺（5-HT）对兔膀胱和尿道肌条的作用。5-HT在逼尿肌和尿道中产生剂量依赖性收缩。
5-HT诱导的收缩可被5-HT3拮抗剂MDL 72222、ICS 205-930和BRL 43694剂量依赖性抑制。未观察到酮色林、麦角新碱或米替平对5-HT收缩反应的影响。
阿托品和α，β-亚甲基ATP均部分阻断了对5-HT的收缩反应。两者共同作用比单独作用产生的抑制作用更强。
阿托品和α，β-亚甲基ATP也抑制了对电场刺激的收缩反应。5-HT3拮抗剂MDL 72222对电场刺激引起的收缩无影响。
5-HT诱导收缩的阿托品和α，β-亚甲基ATP抵抗成分不受5-HT1拮抗剂米替平、5-HT2拮抗剂酮色林和麦角新碱或5-HT3拮抗剂MDL 72222、ICS 205-930和BRL 43694的影响。
河豚毒素、六甲铵、酚妥拉明和哌唑嗪对5-HT的收缩反应无影响。
这些结果表明，在兔下尿路中：（i）存在5-HT3受体；（ii）对5-HT的收缩反应由突触前刺激介导；（iii）存在非肾上腺素能、非胆碱能兴奋性神经传递。
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