用同种异体移植抗原致敏的豚鼠中T淋巴细胞亚群的动力学。
The kinetics of T lymphocyte subpopulations in guinea-pigs sensitized with allogeneic transplantation antigens.
作者信息
Hashim G A, Yee N, Ramey W G
出版信息
Clin Exp Immunol. 1980 Sep;41(3):533-40.
The kinetics of specifically sensitized T lymphocytes in the circulation and lymphoid tissues of guinea-pigs immunized with allogeneic transplantation antigens or with synthetic peptide sequence known to induce delayed-type hypersensitivity were documented by the antigen-stimulated active rosette-forming T cell (AgARFC) assay. The results show that immunologically functional cells sensitized to a particular antigen do not remain in the circulation when the antigenic source has been withdrawn. These cells become sequestered in lymphoid tissue and may be recalled into the circulation shortly after the de novo administration of sensitizing antigen. The detection of antigen-sensitive T cells in the circulation was indicative of the presence of and failure to detect these cells and their eventual appearance in lymphoid tissues was related to depletion of the antigenic source.
通过抗原刺激的活性玫瑰花结形成T细胞（AgARFC）试验，记录了用同种异体移植抗原或已知可诱导迟发型超敏反应的合成肽序列免疫的豚鼠循环和淋巴组织中特异性致敏T淋巴细胞的动力学。结果表明，当抗原来源被撤除时，对特定抗原致敏的免疫功能细胞不会留在循环中。这些细胞被隔离在淋巴组织中，并且在重新给予致敏抗原后不久可能被召回循环中。循环中抗原敏感T细胞的检测表明这些细胞的存在，未能检测到这些细胞以及它们最终在淋巴组织中的出现与抗原来源的耗竭有关。
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