地西泮对蛙肌张力和电解质分布的影响。

The effect of diazepam on tension and electrolyte distribution in frog muscle.

作者信息

Degroof R C, Bianchi C P, Narayan S

出版信息

Eur J Pharmacol. 1980 Aug 29;66(2-3):193-9. doi: 10.1016/0014-2999(80)90142-9.

Abstract

The effect of diazepam on sartorius muscles of the frog was evaluated. Resting tension in sartorius muscle was not affected by diazepam (5 x 10(-5)M) but twitch tension was increased and tetanus tension decreased. The kinetics of 45Ca efflux were altered by diazepam. The calcium content of the intermediate pool was increased by diazepam (5 x 10(-6)M). When the diazepam concentration was increased (5 x 10(-5)M), the time constant of the slow pool decreased and the 45Ca content of the intermediate pool increased further. It is suggested that diazepam interferes with the calcium sequestering system of the sarcoplasmic reticulum (slow pool) and causes an increase of the calcium content of the myofibrillar space (intermediate pool).

摘要

评估了地西泮对青蛙缝匠肌的作用。地西泮（5×10⁻⁵M）对缝匠肌的静息张力无影响，但可增加抽搐张力并降低强直张力。地西泮改变了⁴⁵Ca外流的动力学。地西泮（5×10⁻⁶M）可增加中间池的钙含量。当地西泮浓度增加（5×10⁻⁵M）时，慢池的时间常数减小，中间池的⁴⁵Ca含量进一步增加。提示地西泮干扰肌浆网（慢池）的钙螯合系统，并导致肌原纤维间隙（中间池）的钙含量增加。