Lang C, Gyr K, Kraehenmann J A, Arenz F
J Clin Chem Clin Biochem. 1980 Sep;18(9):551-5. doi: 10.1515/cclm.1980.18.9.551.
The oral pancreatic function test with N-benzoyl-L-tyrosyl-p-aminobenzoic acid was performed on 24 healthy test subjects, and its toxicity was examined. Eight patients with restricted renal function and known renal disease were also investigated. The pancreatic function test and the same procedure using free p-amino-benzoic acid were performed at 2-3-day intervals. During all the investigations with the pancreatic function test, no clinical side effects were observed. All parameters investigated at all the test times fell within the normal range. No toxicity of N-benzoyl-L-tyrosyl-p-amino-benzoic acid could be found. The excretion of p-aminobenzoic acid after administration of N-benzoyl-L-tyrosyl-p-aminobenzoic acid ws greatly reduced in all patients with restricted renal function. Four of eight patients also showed essentially no increase in excretion rate when free p-aminobenzoic acid was given instead of the peptide. It is therefore not possible to correct the pancreatic function test results in patients with renal insufficiency by calculating the ratio of p-aminobenzoic acid excretion after peptide intake to that after free p-aminobenzoic acid ingestion. Adequate renal function is therefore a prerequisite for the pancreatic function test.
对24名健康受试者进行了用N-苯甲酰-L-酪氨酰-对氨基苯甲酸的口服胰腺功能试验，并检测了其毒性。还对8名肾功能受限且患有已知肾脏疾病的患者进行了研究。胰腺功能试验以及使用游离对氨基苯甲酸的相同程序每隔2至3天进行一次。在所有胰腺功能试验研究过程中，未观察到临床副作用。所有检测时间点所研究的所有参数均在正常范围内。未发现N-苯甲酰-L-酪氨酰-对氨基苯甲酸有毒性。在所有肾功能受限的患者中，给予N-苯甲酰-L-酪氨酰-对氨基苯甲酸后对氨基苯甲酸的排泄量大幅降低。8名患者中有4名在给予游离对氨基苯甲酸而非肽时，排泄率基本也没有增加。因此，通过计算摄入肽后对氨基苯甲酸排泄量与摄入游离对氨基苯甲酸后对氨基苯甲酸排泄量的比值来校正肾功能不全患者的胰腺功能试验结果是不可能的。因此，足够的肾功能是胰腺功能试验的一个先决条件。
