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1
Value of serum PABA as a pancreatic function test.血清对氨基苯甲酸作为胰腺功能试验的价值。
Gut. 1984 May;25(5):508-12. doi: 10.1136/gut.25.5.508.
2
BT-PABA test with plasma PABA measurements: evaluation of sensitivity and specificity.采用血浆对氨基苯甲酸（PABA）测量的BT-PABA试验：敏感性和特异性评估
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[Value of the BT-PABA test with serum PABA as a pancreatic function test].[以血清对氨基苯甲酸作为胰腺功能试验的苯替酪胺试验的价值]
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Observations on the BT PABA/14C-PABA tubeless test of pancreatic function.关于胰腺功能的BT对氨基苯甲酸/14C-对氨基苯甲酸无管试验的观察
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Pancreatic function testing: serum PABA measurement is a reliable and accurate measurement of exocrine function.胰腺功能测试：血清对氨基苯甲酸测量是外分泌功能的可靠且准确的测量方法。
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7
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The usefulness of serum PABA measurement after BT-PABA administration in the diagnosis of chronic pancreatitis.给予苯甲酰-L-酪氨酸对氨基苯甲酸（BT-PABA）后测定血清对氨基苯甲酸（PABA）在慢性胰腺炎诊断中的作用。
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Clinical evaluation of pancreatic excretion test with dimethadione and oral BT-PABA test in chronic pancreatitis.二甲双酮胰腺排泄试验与口服BT-PABA试验在慢性胰腺炎中的临床评估
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Glucose Metabolism After Pancreatectomy: Opposite Extremes Between Pancreaticoduodenectomy and Distal Pancreatectomy.胰腺切除术后的糖代谢：胰十二指肠切除术与胰体尾切除术之间的极端差异。
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Function tests in the diagnosis of chronic pancreatitis. Critical evaluation.慢性胰腺炎诊断中的功能试验。批判性评价。
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4
The usefulness of serum PABA measurement after BT-PABA administration in the diagnosis of chronic pancreatitis.给予苯甲酰-L-酪氨酸对氨基苯甲酸（BT-PABA）后测定血清对氨基苯甲酸（PABA）在慢性胰腺炎诊断中的作用。
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Gut. 1988 Dec;29(12):1736-40. doi: 10.1136/gut.29.12.1736.
7
Comparison of BT-PABA test and fecal chymotrypsin measurements in normal subjects and diabetic patients.正常人和糖尿病患者中BT-对氨基苯甲酸试验与粪便糜蛋白酶测量的比较。
Acta Diabetol Lat. 1990 Apr-Jun;27(2):157-64. doi: 10.1007/BF02581287.

本文引用的文献

1
Assessment of exocrine pancreatic function by oral administration of N-benzoyl-L-tyrosyl-p-aminobenzoic acid (Bentiromide): 5 years' clinical experience.口服 N-苯甲酰-L-酪氨酰对氨基苯甲酸（苯替酪胺）评估胰腺外分泌功能：5年临床经验
Br J Surg. 1981 Nov;68(11):771-5. doi: 10.1002/bjs.1800681106.
2
Determination of protease-cleaved p-aminobenzoic acid (PABA) in serum after oral administration of N-benzoyl-L-tyrosyl-p-aminobenzoic acid (PABA-peptide) in children.
Eur J Pediatr. 1981 Feb;135(3):277-9. doi: 10.1007/BF00442103.
3
[Serum paraaminobenzoic acid following the use of N-benzoyl-L-tyrosyl-paraaminobenzoic acid in the diagnosis of pancreatic insufficiency].[使用N-苯甲酰-L-酪氨酰-对氨基苯甲酸诊断胰腺功能不全后血清对氨基苯甲酸的情况]
Schweiz Med Wochenschr. 1981 Mar 7;111(10):343-7.
4
[The NBT-PABA test in the diagnosis of exocrine pancreatic insufficiency (author's transl)].[NBT-PABA试验在诊断外分泌性胰腺功能不全中的应用（作者译）]
Dtsch Med Wochenschr. 1980 Oct 10;105(41):1418-23. doi: 10.1055/s-2008-1070884.
5
BT-PABA test with plasma PABA measurements: evaluation of sensitivity and specificity.采用血浆对氨基苯甲酸（PABA）测量的BT-PABA试验：敏感性和特异性评估
Gut. 1983 Apr;24(4):318-25. doi: 10.1136/gut.24.4.318.
6
[The specificity of peptide-PABA-test (author's transl)].肽 - 对氨基苯甲酸试验的特异性（作者译）
Z Gastroenterol. 1979 May;17(5):310-7.
7
[Indirect assessment of exocrine pancreatic function by oral administration of a synthetic peptide, N-benzoyl-L-tyrosyl-para-amino-benzoic-acid (PABA test) (author's transl)].
Gastroenterol Clin Biol. 1979 Mar;3(3):227-33.
8
[Exocrine pancreatic function test by N-benzoyl-L-tyrosyl-p-aminobenzoic acid (author's transl)].用N-苯甲酰-L-酪氨酸对氨基苯甲酸进行胰腺外分泌功能试验（作者译）
Z Gastroenterol. 1979 Mar;17(3):187-94.
9
[Diagnosis of exocrine pancreatic malfunction with a synthetic peptide specific for chymotrypsine (author's transl)].用针对胰凝乳蛋白酶的合成肽诊断外分泌性胰腺功能障碍（作者译）
Klin Wochenschr. 1978 Feb 15;56(4):197-205. doi: 10.1007/BF01705383.

血清对氨基苯甲酸作为胰腺功能试验的价值。

Value of serum PABA as a pancreatic function test.

作者信息

Lang C, Gyr K, Tonko I, Conen D, Stalder G A

出版信息

Gut. 1984 May;25(5):508-12. doi: 10.1136/gut.25.5.508.

DOI:10.1136/gut.25.5.508
PMID:6609103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1432460/
Abstract

In a total of 71 subjects (19 controls, 24 patients with non-pancreatic gastrointestinal disease, and 27 patients with pancreatic disease) an oral pancreatic function test using N-benzoyl-L-tyrosyl-PABA (BT-PABA) was performed with simultaneous determination of the serum para-aminobenzoic acid (PABA). Urinary excretion of PABA was significantly less (p less than 0.001) in patients with chronic pancreatitis (n = 12) and pancreatic carcinoma (n = 10) than in controls and in patients with non-pancreatic disease. The serum concentration curve in patients with chronic pancreatitis was significantly flattened (p less than 0.001) compared with that of the control group and the patients with non-pancreatic gastrointestinal disease. The discrimination between the controls and the patients with chronic pancreatitis was best at 120 minutes after administration of BT-PABA (lower limit of normal: 2.8 micrograms/ml). The results of our study show that determination of PABA serum concentration two hours after administration of BT-PABA is as valuable an index of pancreatic function as the urinary excretion of PABA.

摘要

对总共71名受试者（19名对照者、24名非胰腺性胃肠道疾病患者和27名胰腺疾病患者）进行了口服N-苯甲酰-L-酪氨酸对氨基苯甲酸（BT-PABA）胰腺功能试验，并同时测定血清对氨基苯甲酸（PABA）。慢性胰腺炎患者（n = 12）和胰腺癌患者（n = 10）的PABA尿排泄量显著低于对照者和非胰腺疾病患者（p < 0.001）。与对照组和非胰腺性胃肠道疾病患者相比，慢性胰腺炎患者的血清浓度曲线明显变平（p < 0.001）。在给予BT-PABA后120分钟时，对照者与慢性胰腺炎患者之间的区分效果最佳（正常下限：2.8微克/毫升）。我们的研究结果表明，给予BT-PABA两小时后测定PABA血清浓度与PABA尿排泄量一样，都是评估胰腺功能的有价值指标。