血清对氨基苯甲酸作为胰腺功能试验的价值。
Value of serum PABA as a pancreatic function test.
作者信息
Lang C, Gyr K, Tonko I, Conen D, Stalder G A
出版信息
Gut. 1984 May;25(5):508-12. doi: 10.1136/gut.25.5.508.
In a total of 71 subjects (19 controls, 24 patients with non-pancreatic gastrointestinal disease, and 27 patients with pancreatic disease) an oral pancreatic function test using N-benzoyl-L-tyrosyl-PABA (BT-PABA) was performed with simultaneous determination of the serum para-aminobenzoic acid (PABA). Urinary excretion of PABA was significantly less (p less than 0.001) in patients with chronic pancreatitis (n = 12) and pancreatic carcinoma (n = 10) than in controls and in patients with non-pancreatic disease. The serum concentration curve in patients with chronic pancreatitis was significantly flattened (p less than 0.001) compared with that of the control group and the patients with non-pancreatic gastrointestinal disease. The discrimination between the controls and the patients with chronic pancreatitis was best at 120 minutes after administration of BT-PABA (lower limit of normal: 2.8 micrograms/ml). The results of our study show that determination of PABA serum concentration two hours after administration of BT-PABA is as valuable an index of pancreatic function as the urinary excretion of PABA.
对总共71名受试者（19名对照者、24名非胰腺性胃肠道疾病患者和27名胰腺疾病患者）进行了口服N-苯甲酰-L-酪氨酸对氨基苯甲酸（BT-PABA）胰腺功能试验，并同时测定血清对氨基苯甲酸（PABA）。慢性胰腺炎患者（n = 12）和胰腺癌患者（n = 10）的PABA尿排泄量显著低于对照者和非胰腺疾病患者（p < 0.001）。与对照组和非胰腺性胃肠道疾病患者相比，慢性胰腺炎患者的血清浓度曲线明显变平（p < 0.001）。在给予BT-PABA后120分钟时，对照者与慢性胰腺炎患者之间的区分效果最佳（正常下限：2.8微克/毫升）。我们的研究结果表明，给予BT-PABA两小时后测定PABA血清浓度与PABA尿排泄量一样，都是评估胰腺功能的有价值指标。
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