• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Phencyclidine-induced psychosis.

作者信息

Allen R M, Young S J

出版信息

Am J Psychiatry. 1978 Sep;135(9):1081-4. doi: 10.1176/ajp.135.9.1081.

DOI:10.1176/ajp.135.9.1081
PMID:696930
Abstract

During a 13-month period, 9 patients with phencyclidine-induced psychosis were admitted to Darnall Army Hospital. They exhibited hostility agitation, and tangentiality and had delusions of influence and religious grandiosity. Six subjects reported auditory hallucinations, and 4 were disoriented in at least 1 sphere. Despite treatment with antipsychotic medication, the psychotic episodes often persisted for more than 30 days. Our clinical finding of prolonged psychotic reactions, together with previous reports of the effects of phencyclidine, suggests that phenycyclidine provides an intriguing drug model for schizophrenia.

摘要

相似文献

1
Phencyclidine-induced psychosis.
Am J Psychiatry. 1978 Sep;135(9):1081-4. doi: 10.1176/ajp.135.9.1081.
2
Prolonged psychosis attributed to phencyclidine: report of three cases.苯环利定所致的持续性精神病:三例报告
Am J Psychiatry. 1975 Oct;132(10):1076-8. doi: 10.1176/ajp.132.10.1076.
3
Augmentation of haloperidol by ascorbic acid in phencyclidine intoxication.
Am J Psychiatry. 1987 Sep;144(9):1207-9. doi: 10.1176/ajp.144.9.1207.
4
Psychiatric sequelae of phencyclidine abuse.苯环利定滥用的精神后遗症。
Clin Toxicol. 1976;9(4):529-38. doi: 10.3109/15563657608988154.
5
Treatment of phenylcyclohexylpyrrolidine (PHP) psychosis with haloperidol.
J Toxicol Clin Toxicol. 1985;23(2-3):185-9. doi: 10.3109/15563658508990627.
6
Reserpine and PCP psychosis.
Am J Psychiatry. 1979 Dec;136(12):1618-9.
7
Phencyclidine poisoning.苯环利定中毒
JAMA. 1975 Nov 3;234(5):512-3.
8
Phencyclidine and ketamine intoxication: a study of four populations of recreational users.苯环利定和氯胺酮中毒:对四类娱乐性使用者群体的研究。
NIDA Res Monogr. 1978 Aug(21):119-47.
9
Comparison of chlorpromazine, haloperidol and pimozide in the treatment of phencyclidine psychosis: DA-2 receptor specificity.
J Toxicol Clin Toxicol. 1984;22(6):573-9. doi: 10.3109/15563658408992586.
10
Phenomenologic comparison of the idiopathic psychosis of schizophrenia and drug-induced cocaine and phencyclidine psychoses: a retrospective study.精神分裂症特发性精神病与药物所致可卡因和苯环利定精神病的现象学比较:一项回顾性研究。
Clin Neuropharmacol. 1994 Aug;17(4):359-69. doi: 10.1097/00002826-199408000-00008.

引用本文的文献

1
Future Perspectives of NMDAR in CNS Disorders.N-甲基-D-天冬氨酸受体在中枢神经系统疾病中的未来展望
Molecules. 2025 Feb 14;30(4):877. doi: 10.3390/molecules30040877.
2
A Dynamic Entropy Approach Reveals Reduced Functional Network Connectivity Trajectory Complexity in Schizophrenia.一种动态熵方法揭示了精神分裂症中功能网络连接轨迹复杂性的降低。
Entropy (Basel). 2024 Jun 26;26(7):545. doi: 10.3390/e26070545.
3
mGluR5 positive allosteric modulation prevents MK-801 induced increases in extracellular glutamate in the rat medial prefrontal cortex.
mGluR5 正变构调节剂可预防 MK-801 诱导的大鼠前额皮质细胞外谷氨酸增加。
Neuroscience. 2024 Sep 13;555:83-91. doi: 10.1016/j.neuroscience.2024.06.016. Epub 2024 Jul 15.
4
Effects of N-Methyl-d-Aspartate Receptor Antagonists on Gamma-Band Activity During Auditory Stimulation Compared With Electro/Magneto-encephalographic Data in Schizophrenia and Early-Stage Psychosis: A Systematic Review and Perspective.N-甲基-D-天冬氨酸受体拮抗剂对听觉刺激期间γ波段活动的影响与精神分裂症和早期精神病的脑电/磁图数据的比较:系统评价和观点。
Schizophr Bull. 2024 Aug 27;50(5):1104-1116. doi: 10.1093/schbul/sbae090.
5
A Kpna1-deficient psychotropic drug-induced schizophrenia model mouse for studying gene-environment interactions.用于研究基因-环境相互作用的 Kpna1 缺陷型精神分裂症模型小鼠。
Sci Rep. 2024 Feb 9;14(1):3376. doi: 10.1038/s41598-024-53237-3.
6
Phencyclidine-Like Abuse Liability and Psychosis-Like Neurocognitive Effects of Novel Arylcyclohexylamine Drugs of Abuse in Rodents.新型芳基环己基胺类滥用药物在啮齿类动物中的苯环己哌啶样滥用倾向和类精神病神经认知效应。
J Pharmacol Exp Ther. 2024 Jun 21;390(1):14-28. doi: 10.1124/jpet.123.001942.
7
Understanding the role of the NMDA receptor subunit, GluN2D, in mediating NMDA receptor antagonist-induced behavioral disruptions in male and female mice.了解N-甲基-D-天冬氨酸(NMDA)受体亚基GluN2D在介导NMDA受体拮抗剂引起的雄性和雌性小鼠行为紊乱中的作用。
J Neurosci Res. 2024 Jan;102(1):e25257. doi: 10.1002/jnr.25257. Epub 2023 Oct 10.
8
Using Nonhuman Primate Models to Reverse-Engineer Prefrontal Circuit Failure Underlying Cognitive Deficits in Schizophrenia.利用非人灵长类动物模型逆向工程精神分裂症认知缺陷背后的前额叶回路故障。
Curr Top Behav Neurosci. 2023;63:315-362. doi: 10.1007/7854_2022_407.
9
Glutamatergic dysfunction in Schizophrenia.精神分裂症中的谷氨酸能功能障碍。
Transl Psychiatry. 2022 Dec 3;12(1):500. doi: 10.1038/s41398-022-02253-w.
10
Effects of Taurine in Mice and Zebrafish Behavioral Assays With Translational Relevance to Schizophrenia.牛磺酸对具有精神分裂症转化相关性的小鼠和斑马鱼行为分析的影响。
Int J Neuropsychopharmacol. 2023 Feb 14;26(2):125-136. doi: 10.1093/ijnp/pyac073.