在新斯的明处理过的青蛙肌肉中，终板电流的衰减被乙酰胆碱或筒箭毒碱所阻断。
The decay of end-plate currents in neostigmine-treated frog muscle blocked by acetylcholine or tubocurarine.
作者信息
Guinan J J
出版信息
J Physiol. 1980 Aug;305:345-55. doi: 10.1113/jphysiol.1980.sp013368.
Abstract
- The decay times of e.p.c.s. (with acetylcholinesterase inhibited by neostigmine) were measured with a view to inferring the extent of acetylcholine (ACh) binding. 2. E.p.c.s from muscles blocked by ACh decayed at less than half the rate of e.p.c.s. from muscles blocked by tubocurarine, and slightly more slowly than m.e.p.c.s. from unblocked muscles. 3. ACh prolonged e.p.c.s and reduced their amplitudes when added to muscles blocked by tubocurarine. 4. After treatment with alpha-bungarotoxin, some e.p.c.s. from muscles blocked by ACh were prolonged relative to e.p.c.s from muscles blocked by tubocurarine. 5. These phenomena are interpreted as indicating that either (a) desensitized receptors bind ACh and prolong e.p.c.s by buffered diffusion or (b) in highly desensitized muscles there is a population of active receptors which bind ACh for many milliseconds.
摘要
- 测量了新斯的明抑制乙酰胆碱酯酶时终板电流（e.p.c.s.）的衰减时间，以推断乙酰胆碱（ACh）的结合程度。2. 由乙酰胆碱阻断的肌肉产生的终板电流衰减速度不到由筒箭毒碱阻断的肌肉产生的终板电流衰减速度的一半，且比未阻断肌肉产生的微小终板电流（m.e.p.c.s.）衰减速度稍慢。3. 当将乙酰胆碱添加到由筒箭毒碱阻断的肌肉中时，它会延长终板电流并降低其幅度。4. 用α-银环蛇毒素处理后，相对于由筒箭毒碱阻断的肌肉产生的终板电流，由乙酰胆碱阻断的肌肉产生的一些终板电流会延长。5. 这些现象被解释为表明：要么（a）脱敏受体结合乙酰胆碱并通过缓冲扩散延长终板电流；要么（b）在高度脱敏的肌肉中存在一群活性受体，它们能结合乙酰胆碱达数毫秒之久。
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