Fontaine J, Reuse J
Eur J Pharmacol. 1980 Nov 7;68(1):55-60. doi: 10.1016/0014-2999(80)90060-6.
The substituted benzamides metoclopramide, bromopride, tiapride and sulpiride (10(-5) and 10(-4) M) significantly increased the sensitivity of frog rectus abdominis muscle to exogenous acetylcholine but not to carbachol. This supersensitivity could be correlated with the anticholinesterase activity of these drugs measured in homogenates from frog skeletal muscle. Sultopride, like procainamide, has only inhibitory effects on the responses of the rectus abdominis to acetylcholine and has no anticholinesterase activity in this preparation.
取代苯甲酰胺类药物甲氧氯普胺、溴必利、硫必利和舒必利（10⁻⁵和10⁻⁴ M）可显著提高蛙腹直肌对外源性乙酰胆碱的敏感性，但对卡巴胆碱不敏感。这种超敏感性可能与这些药物在蛙骨骼肌匀浆中测得的抗胆碱酯酶活性有关。舒托必利与普鲁卡因胺一样，对腹直肌对乙酰胆碱的反应仅有抑制作用，且在此制剂中无抗胆碱酯酶活性。
