LeFree M T, Vogel R A, Kirch D L, Steele P P
J Nucl Med. 1981 Jan;22(1):48-54.
A single-photon emission tomography system was developed and studied. Based upon a seven-pinhile-collimated Anger camera, interfaced to a digital minicomputer, this imaging configuration yielded seven independent, nonoverlapping projection images of the radioactivity in a commonly viewed volume. The computer was used to implement an iterative algorithm that processed these projections to yield a three-dimensional reconstruction of the soruce distribution. The algorithm provudes a nonlinear first approximation to the reconstruction, then use a single iteration technique to reduce errors resulting from that approximation. Point spread functions (PSF) at various distances from the collimator face, and point-source sensitivity (PSS) at a location in the middle of the reconstruction volume were determined. The system was used for thallium-201 imaging, where it was shown to reduce imaging time and increase sensitivity without loss in specificity when compared with standard parallel-hole-collimated imaging. Seven-pinhole tomography is a practical three-dimensional imaging system that has been demonstrated to be useful in the emission cardiology setting.
开发并研究了一种单光子发射断层扫描系统。该成像配置基于一台七针孔准直的安格尔相机，并与一台数字小型计算机相连，可在一个共同观察的体积内生成七个独立的、不重叠的放射性投影图像。计算机用于实现一种迭代算法，该算法处理这些投影以生成源分布的三维重建。该算法提供了重建的非线性一阶近似，然后使用单迭代技术来减少该近似产生的误差。确定了距准直器表面不同距离处的点扩散函数（PSF）以及重建体积中间位置的点源灵敏度（PSS）。该系统用于铊-201成像，结果表明，与标准平行孔准直成像相比，它可减少成像时间并提高灵敏度，且不损失特异性。七针孔断层扫描是一种实用的三维成像系统，已证明在发射心脏病学领域很有用。
