慢性小脑刺激治疗脑瘫：一项双盲研究。

Chronic cerebellar stimulation for cerebral palsy: a double-blind study.

作者信息

Gahm N H, Russman B S, Cerciello R L, Fiorentino M R, McGrath D M

出版信息

Neurology. 1981 Jan;31(1):87-90. doi: 10.1212/wnl.31.1.87.

DOI:10.1212/wnl.31.1.87

Abstract

A double-blind, crossover technique was devised to assess the value of chronic cerebellar stimulation in children with cerebral palsy. Cerebellar stimulators were implanted in eight children and adolescents with cerebral palsy. The external transmitter was changed monthly during each of the first 3 months and was set to be functional or placebo by random assignment. Objective assessment by physical, occupational, and speech therapists as well as by a neurologist failed to document significant improvement in any of the participants. Some children became less spastic and developed increased mental alertness and improved clarity of speech. However, these improvements occurred during placebo periods as often as with stimulation.

摘要

设计了一种双盲交叉技术来评估慢性小脑刺激对脑瘫患儿的价值。为8名患有脑瘫的儿童和青少年植入了小脑刺激器。在最初的3个月中，外部发射器每月更换一次，并通过随机分配设置为开启或安慰剂状态。由物理治疗师、职业治疗师、言语治疗师以及神经科医生进行的客观评估未能证明任何参与者有显著改善。一些儿童的痉挛程度减轻，精神警觉性提高，言语清晰度改善。然而，这些改善在安慰剂期和刺激期出现的频率相同。