Miller A M, Gross M A, Yunis A A
Exp Hematol. 1980 Mar;8(3):236-42.
Human granulocyte-macrophage progenitor cells (CFUc) fractionated by velocity sedimentation at unit gravity exhibit heterogeneity with respect to inhibition by the drug chloramphenicol (CAP). An inverse correlation is observed between sedimentation velocity and sensitivity to CAP, e.g., increasing sensitivity with decreasing velocity. This heterogeneity is not a result of protection by endogenously produced colony stimulating factor since the same result obtains after removal of adherent cell populations. This heterogeneity in CFUc sensitivity to CAP may be a determining factor on the variability of bone marrow suppression by the drug.
通过单位重力下的速度沉降分离的人粒细胞 - 巨噬细胞祖细胞（CFUc）对氯霉素（CAP）的抑制表现出异质性。观察到沉降速度与对CAP的敏感性之间呈负相关，例如，随着速度降低敏感性增加。这种异质性不是内源性产生的集落刺激因子保护的结果，因为去除贴壁细胞群体后也得到相同的结果。CFUc对CAP敏感性的这种异质性可能是该药物骨髓抑制变异性的一个决定性因素。
