Motomura S, Dexter T M
Exp Hematol. 1980 Mar;8(3):298-303.
The effect of prostaglandin E1 (PGE1) on the proliferation and differentiation of hemopoietic stem cells has been studied in a long-term bone marrow liquid culture system. In cultures supplemented with PGE1, there was a dose dependent decrease in both CFUS and CFUc. (CSA levels rose dose dependently, with a concomitant increase in mature granulocyte production. Macrophage production was suppressed.) After cessation of PGE1 treatment, CFUS and CFUc returned gradually to the control values and CSA was not detectable. There was no significant effect on hemopoiesis in cultures supplemented with 10(-8) M or less concentrations.
在长期骨髓液体培养系统中研究了前列腺素E1（PGE1）对造血干细胞增殖和分化的影响。在添加PGE1的培养物中，CFUS和CFUc均呈剂量依赖性降低。（CSA水平呈剂量依赖性升高，同时成熟粒细胞产量增加。巨噬细胞产量受到抑制。）停止PGE1处理后，CFUS和CFUc逐渐恢复至对照值，且未检测到CSA。在添加浓度为10（-8）M或更低的培养物中，对造血没有显著影响。
