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成人钙化性主动脉瓣狭窄的主动脉瓣成形术。

Aortic valvuloplasty for calcific aortic stenosis in the adult.

作者信息

Weinstein G S, Reed W A, Killen D A

出版信息

J Cardiovasc Surg (Torino). 1980 Nov-Dec;21(6):675-80.

PMID:6970199
Abstract

From July, 1971, through February, 1979, thirty-eight highly selected adult patients with symptomatic aortic stenosis (N.Y.H.A. Class III to IV) underwent aortic valvuloplasty rather than valve replacement. The choice of aortic valvuloplasty was based on the presence of one or more of the following factors: advanced age (over 75 years), calcification of the aorta and/or aortic annulus, small aortic annulus, severe coronary artery disease, poor left ventricular function (ejection fraction less than 25%), difficulty in coronary cannulation, or contraindication to anticoagulation. In addition, patients with the combination of severe coronary artery disease and aortic stenosis of insufficient severity to warrant valve replacement were teated by aortic valvuloplasty at the time of coronary artery bypass. The gradient across the aortic valve averaged 61.7 mmHg preoperatively and 8.4 mmHg postoperatively. There were two operative deaths (one from pre-existing renal failure) and two late deaths (pulmonary embolus and CHF). No patients were lost to follow-up. Thirty-two of thirty-four surviving patients experienced initial functional improvement. Five patients developed recurrent aortic stenosis (mean time 42.8 months after operation); and four required reoperation. The five year actuarial survival was 85.7% with a mean follow-up period of 24.8 months (range 1 to 91 months). The results in this high-risk subset of patients suggest that aortic valvuloplasty has a definite place in the treatment of selected cases of aortic stenosis.

摘要

从1971年7月至1979年2月,38例经过严格挑选的有症状的主动脉瓣狭窄成年患者(纽约心脏协会心功能分级为III至IV级)接受了主动脉瓣成形术而非瓣膜置换术。选择主动脉瓣成形术基于以下一个或多个因素:高龄(75岁以上)、主动脉和/或主动脉环钙化、主动脉环小、严重冠状动脉疾病、左心室功能差(射血分数小于25%)、冠状动脉插管困难或抗凝禁忌。此外,患有严重冠状动脉疾病且主动脉瓣狭窄程度不足以进行瓣膜置换的患者在冠状动脉搭桥时接受主动脉瓣成形术治疗。术前主动脉瓣跨瓣压差平均为61.7 mmHg,术后为8.4 mmHg。有2例手术死亡(1例死于术前存在的肾衰竭)和2例晚期死亡(肺栓塞和心力衰竭)。没有患者失访。34例存活患者中有32例最初功能得到改善。5例患者出现复发性主动脉瓣狭窄(平均术后时间42.8个月);4例需要再次手术。5年精算生存率为85.7%,平均随访期为24.8个月(范围1至91个月)。这一高危患者亚组的结果表明,主动脉瓣成形术在某些主动脉瓣狭窄病例的治疗中具有明确的地位。

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