Goodman M M, Elmaleh D R, Kearfott K J, Ackerman R H, Hoop B, Brownell G L, Alpert N M, Strauss H W
J Nucl Med. 1981 Feb;22(2):138-44.
Glucose is the major physiological substrate of the brain and an important physiological substrate for the myocardium. [19F]fluoro-3-deoxy-glucose [3-FDG(F-18)] was studied to determine whether it is a suitable tracer for evaluating the metabolic function of the brain and myocardium. 3-FDG(F-18) was rapidly accumulated in the mouse myocardium (10-12% injected dose/g) and remained constant up to 120 min. Blood, liver, and lung activities exhibited a rapid accumulation of activity (4% injected dose/g) at 1 min, followed by elimination of activity up to 30 min (2% injected dose/g), and then remaining unchanged for a period of 120 min. The arterial blood curve in the dog was fit best by three exponential components (T 1/2 = 0.52 min, 2.75 min, and 142.8 min). Transverse-section images were obtained of the dog's brain and myocardium. From sequential two-dimensional images, a clearance half-time of 26.88 min was determined for the canine brain. Radiation doses for man were calculated from tissue distribution data for mice.
葡萄糖是大脑的主要生理底物，也是心肌的重要生理底物。研究了[19F]氟-3-脱氧葡萄糖[3-FDG(F-18)]，以确定它是否是评估大脑和心肌代谢功能的合适示踪剂。3-FDG(F-18)在小鼠心肌中迅速蓄积(10-12%注射剂量/克)，并在120分钟内保持恒定。血液、肝脏和肺的放射性在1分钟时迅速蓄积(4%注射剂量/克)，随后在30分钟内放射性消除(2%注射剂量/克)，然后在120分钟内保持不变。犬的动脉血曲线最适合用三个指数成分拟合(T1/2 = 0.52分钟、2.75分钟和142.8分钟)。获得了犬脑和心肌的横断面图像。从连续的二维图像中，确定犬脑的清除半衰期为26.88分钟。根据小鼠的组织分布数据计算了人体的辐射剂量。
