用于组织代谢研究的2-和3-18F-氟代脱氧-D-葡萄糖的比较。

Comparison of 2- and 3-18F-fluoro-deoxy-D-glucose for studies of tissue metabolism.

作者信息

Kearfott K J, Elmaleh D R, Goodman M, Correia J A, Alpert N M, Ackerman R H, Brownell G L, Strauss W H

出版信息

Int J Nucl Med Biol. 1984;11(1):15-22. doi: 10.1016/0047-0740(84)90023-8.

Abstract

2- and 3-18F-fluoro-deoxy-D-glucose were proposed as sugar analogs to study glucose metabolism in brain and heart tissues. To evaluate their usefulness, the in vivo behavior of 2- 28FDG and 3-18FDG was investigated in mice and rats and for 3-18FDG in dogs at various times post-injection. Positron emission tomographic (PET) imaging was performed for heart and brain of anesthetized dogs with both radiopharmaceuticals. In all species studied, a higher uptake in brain, heart and kidney was observed for 2-18FDG compared with 3-18FDG. Radioactivity also cleared blood and liver more rapidly with 2-18FDG than with 3-18FDG. Estimates of brain kinetic model parameters revealed the metabolic trapping of 2-18FDG, making this agent favorable for studies of tissue metabolism, and the relative lack of phosphorylation of 3-18FDG, which makes it a potential agent for studies of glucose transport.

摘要

2-和3-18F-氟代脱氧-D-葡萄糖被提议作为糖类似物，用于研究脑和心脏组织中的葡萄糖代谢。为评估它们的效用，在小鼠和大鼠中研究了2-28FDG和3-18FDG的体内行为，并在注射后不同时间对狗体内的3-18FDG进行了研究。用这两种放射性药物对麻醉狗的心脏和大脑进行了正电子发射断层扫描（PET）成像。在所有研究的物种中，与3-18FDG相比，2-18FDG在脑、心脏和肾脏中的摄取更高。2-18FDG清除血液和肝脏中的放射性也比3-18FDG更快。脑动力学模型参数估计显示2-18FDG存在代谢捕获，这使得该试剂有利于组织代谢研究，而3-18FDG相对缺乏磷酸化，这使其成为研究葡萄糖转运的潜在试剂。