Woossmann H, Zeschke G, Nitschkoff S
Anat Anz. 1978;143(5):495-500.
Following implantation of an ultrasonic transducer in the aortic wall of the rabbit, media destructions and pressure necrosis were ascertained when the transducer was fitted closley around the vessel. When the transducer however was fitted widley around the vessel few departures from the normal structure were registered. After ultrasound stress 0.2--0.5 Watt/cm2 5 Min. per die with a mean exposition at 86.6 days, necrosis of the media and proliferations of the intima were noted in the area of the ultrasound application. When the transducer were not protected this resulted in sharp incisures of the vessels giving undeniable proof of ultrasound damages in spite of the low efficiency. Alltogether the histological findings show, that provided correct methodology vasal measurement of blood is possible in chronic experiments.
在兔主动脉壁植入超声换能器后,当换能器紧密贴合血管时,可确定有中膜破坏和压力性坏死。然而,当换能器宽松地贴合血管时,几乎未发现与正常结构的偏差。在超声应力为0.2 - 0.5瓦特/平方厘米,每次5分钟,平均暴露86.6天之后,在超声作用区域观察到中膜坏死和内膜增生。当换能器未加保护时,尽管效率较低,但仍导致血管出现明显切口,这无可辩驳地证明了超声损伤的存在。总的来说,组织学研究结果表明,在慢性实验中,采用正确的方法进行血管内血液测量是可行的。