Turss R
Klin Monbl Augenheilkd. 1980 Dec;177(6):794-7. doi: 10.1055/s-2008-1057729.
In severe zoster keratitis many pathogenic factors are involved. In addition to viral manifestations, the cornea is often affected by anterior uveitis or secondary glaucoma. Neuroparalytic keratitis causes lowered blinking frequency and decreased tear secretion. In addition, zoster ulcerations of the upper lid margin mechanically disturb reformation of the tear film and weaken the lipid layer by necrosis of the Meibomian glands. Ointments reduce break-up time and parasympathicolytic mydriatics further decrease tear secretion. When the average time between two blinks is shorter than the tear film break-up time, a "dry eye" condition usually develops. The appropriate treatment in such cases is thorough prevention of evaporation.
在严重的带状疱疹性角膜炎中,涉及多种致病因素。除了病毒表现外,角膜常受前葡萄膜炎或继发性青光眼影响。神经麻痹性角膜炎导致眨眼频率降低和泪液分泌减少。此外,上睑缘的带状疱疹溃疡会机械性干扰泪膜的重塑,并通过睑板腺坏死削弱脂质层。眼膏会缩短泪膜破裂时间,而抗胆碱能散瞳剂会进一步减少泪液分泌。当两次眨眼之间的平均时间短于泪膜破裂时间时,通常会出现“干眼”状况。在这种情况下,适当的治疗方法是彻底防止泪液蒸发。