Gonschewski H H, Stempel G
Fortschr Med. 1981 Mar 12;99(10):357-60.
In a controlled blind study sputum of 84 patients suffering from chronic bronchitis was bacteriologically examined prior to treatment. Hereby resistance against azidocillin was exhibited by six of the pathogenic agents or the suspected ones; the bacteria in 18 samples of sputum showed resistance against co-trimoxazol. Azidocillin demonstrated, as opposed to co-trimoxazol, slight yet not significant advantages in the elimination of the agents. Azidocillin was, however, significantly superior to co-trimoxazol in the physicians total assessment, which included the clinical process as well as the components of the sputum. According to the results of our investigations, the treatment of chronic bronchitis can be started without examining the sputum. However, in patients showing exacerbation of chronic bronchitis with life-threatening complications, the sputum should be examined before medication is conducted. In such cases we recommend the treatment to be started immediately with an appropriate bactericide like azidocillin and to be continued till the result of the antibiogram is finally established.
在一项对照盲法研究中，对84例慢性支气管炎患者治疗前的痰液进行了细菌学检查。结果发现，六种病原体或疑似病原体对叠氮西林耐药；18份痰液样本中的细菌对复方新诺明耐药。与复方新诺明相比，叠氮西林在清除病原体方面显示出轻微但不显著的优势。然而，在医生的总体评估中，叠氮西林明显优于复方新诺明，总体评估包括临床过程以及痰液成分。根据我们的调查结果，慢性支气管炎的治疗可以在不检查痰液的情况下开始。然而，对于慢性支气管炎急性加重且伴有危及生命并发症的患者，应在用药前检查痰液。在这种情况下，我们建议立即开始使用合适的杀菌剂如叠氮西林进行治疗，并持续至最终确定抗菌谱结果。
