Lacy P E
Monogr Pathol. 1980;21:156-65.
In the short span of 6 years, remarkable advances have been made in islet transplantation. Techniques have been developed which permit the successful reversal of the diabetic state in rats by transplanting isografts of either adult islets, dispersed neonatal pancreases or fetal pancreatic tissue. Islet transplantation prevents or reverses early microvascular complications of the diabetic state in animals. The immune barrier has been bent by simple in vitro procedures which apparently alter the passenger leucocytes of the islets and thus markedly prolong allograft survival. The safety of islet transplant procedures has been established in man. Hopefully, future investigations will continue the bending and lead to the breaking of the immune barrier so that it can be determined whether islet transplantation in man will prevent, arrest or reverse the microvascular, macrovascular and neurological complications that occur in the diabetic patient.
在短短6年时间里，胰岛移植取得了显著进展。已经开发出一些技术，通过移植成年胰岛、分散的新生胰腺或胎儿胰腺组织的同基因移植，能够成功逆转大鼠的糖尿病状态。胰岛移植可预防或逆转动物糖尿病状态的早期微血管并发症。通过简单的体外程序改变了胰岛的过客白细胞，从而显著延长了同种异体移植的存活时间，免疫屏障已被突破。胰岛移植程序在人体中的安全性已经确立。有望未来的研究将继续突破免疫屏障并最终打破它，以便确定人体胰岛移植是否能预防、阻止或逆转糖尿病患者出现的微血管、大血管和神经并发症。
