McLaren A, Chandler P, Buehr M, Fierz W, Simpson E
Nature. 1981 Apr 9;290(5806):513-4. doi: 10.1038/290513a0.
Steele and Gorczynski have recently suggested that inbred male mice rendered tolerant at birth to the alloantigens of an H-2 plus non-H-2 incompatible inbred strain can transmit this tolerance or hyporeactivity, as measured in a primary anti-H-2 cytotoxic T-cell test in vitro, to their progeny, born of normally reactive females syngeneic with the males. As a corollary, it might be expected that the progeny of tetraparental males which are tolerant because from earliest fetal development they are chimaeric with respect to all tissues, including haematopoietic cells and germ cells, might in turn be tolerant to the other set of paternal alloantigens. We have now found, on the contrary, that inbred progeny of one component of a tetraparental male showed heightened responsiveness to the other paternal alloantigens.
斯蒂尔和戈尔钦斯基最近提出，出生时对H-2加非H-2不相容近交系的同种异体抗原产生耐受的近交雄性小鼠，能够将这种耐受性或低反应性（在体外初次抗H-2细胞毒性T细胞试验中测得）传递给它们与正常反应性雌性同基因的雄性所生的后代。由此推论，可以预期，由于从最早的胎儿发育阶段起就对包括造血细胞和生殖细胞在内的所有组织呈嵌合状态而产生耐受的四亲代雄性小鼠的后代，可能反过来对另一组父本同种异体抗原产生耐受。相反，我们现在发现，四亲代雄性小鼠一个组成部分的近交后代对另一父本同种异体抗原表现出增强的反应性。
