Stitz L, Zinkernagel R M
Immunology. 1984 Jun;52(2):205-9.
Male lymphocytic choriomeningitis (LCM) virus-carrier mice were mated to uninfected females and their offsprings tested for (i) LCMV virus and (ii) their potential to generate LCM virus-specific cytotoxic T cells. Among about 500 offspring tested no example of antigen-independent inheritance of tolerance to LCM virus was detected. Therefore inheritance of acquired tolerance cannot be observed in this murine infectious disease model.
将雄性淋巴细胞性脉络丛脑膜炎(LCM)病毒携带小鼠与未感染的雌性小鼠交配,并对它们的后代进行检测,以确定(i)是否存在LCM病毒以及(ii)它们产生LCM病毒特异性细胞毒性T细胞的潜力。在大约500只接受检测的后代中,未检测到对LCM病毒耐受性的抗原非依赖性遗传实例。因此,在这个小鼠传染病模型中无法观察到获得性耐受性的遗传现象。