获得性免疫耐受性是否具有遗传可传递性？
Is acquired immunological tolerance genetically transmissible?
作者信息
Nisbet-Brown E, Wegmann T G
出版信息
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5826-8. doi: 10.1073/pnas.78.9.5826.
Abstract
We have attempted to verify that acquired characteristics can be transmitted through the male germ line by using as a model system the vertical transmission of specific immunological tolerance to major histocompatibility antigens. Tolerant males were a tetraparental mouse and separated parabionts, in each case showing stable lymphoid chimerism. Tolerance in the progeny was assessed by two in vivo assays, rejection of cardiac allografts and clearance of 131I-labeled tumor cells. We were unable to find evidence for heritability of the tolerant state in tetraparental or parabiont males, with either assay system.
摘要
我们试图通过将对主要组织相容性抗原的特异性免疫耐受性的垂直传递作为模型系统，来验证获得性特征是否可通过雄性生殖系进行传递。耐受性雄性包括四亲本小鼠和联体共生小鼠，在每种情况下均表现出稳定的淋巴嵌合现象。通过两种体内试验评估后代的耐受性，即心脏同种异体移植排斥反应和131I标记肿瘤细胞的清除情况。在四亲本或联体共生雄性中，使用任何一种试验系统，我们都未能找到耐受状态具有遗传性的证据。
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引用本文的文献
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The question of inheritance of immunological tolerance.免疫耐受性的遗传问题。
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本文引用的文献
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Supposed lamarckian inheritance of immunological tolerance.假定免疫耐受性的拉马克式遗传。
Nature. 1981 Apr 9;290(5806):508-12. doi: 10.1038/290508a0.
2
Immune reactivity of progeny of tetraparental male mice.四亲本雄性小鼠后代的免疫反应性
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Inheritance of acquired immunological tolerance to foreign histocompatibility antigens in mice.小鼠对外源组织相容性抗原获得性免疫耐受性的遗传
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Simultaneous yet independent inheritance of somatically acquired tolerance to two distinct H-2 antigenic haplotype determinants in mice.小鼠对两种不同的H-2抗原单倍型决定簇体细胞获得性耐受的同时且独立遗传。
Nature. 1981 Feb 19;289(5799):678-81. doi: 10.1038/289678a0.
5
Death and metastatic distribution of tumor cells in mice monitored with 125I-iododeoxy-uridine.用¹²⁵I-碘脱氧尿苷监测小鼠体内肿瘤细胞的死亡和转移分布。
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Parasexual-sexual hybridization--heritable transformation of germ cells in chimeric mice.准性-有性杂交——嵌合小鼠生殖细胞的可遗传转化
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