Wick M R, Nichols W C, Ingle J N, Bruckman J E, Okazaki H
Cancer. 1981 Apr 15;47(8):2036-43. doi: 10.1002/1097-0142(19810415)47:8<2036::aid-cncr2820470823>3.0.co;2-9.
Histologic features of an invasive mediastinal tumor found in a 25-year-old woman fulfilled the accepted criteria for diagnosis of predominantly lymphocytic thymoma. Histochemical and cell marker studies indicated that the neoplasm contained a preponderance of T lymphocytes. After surgical debulking of the mass, aggressive radiotherapy and chemotherapy eradicated all evidence of thoracic disease. However, six months after the initial diagnosis, rapid development of cranial nerve and brainstem metastases--without detectable recurrent disease elsewhere--resulted in the patient's death. Autopsy examination revealed the presence of peripheral nerve metastases as well. A review of the literature disclosed fewer than 10 cases of central nervous system metastasis from thymoma. In only two of these were there clinicopathologic features similar to those seen in this case.
一名25岁女性体内发现的侵袭性纵隔肿瘤的组织学特征符合主要为淋巴细胞性胸腺瘤的公认诊断标准。组织化学和细胞标志物研究表明，该肿瘤含有大量T淋巴细胞。在对肿块进行手术减瘤后，积极的放疗和化疗消除了胸部疾病的所有迹象。然而，在最初诊断六个月后，颅神经和脑干转移迅速发展——其他部位未发现复发性疾病——导致患者死亡。尸检发现也存在周围神经转移。文献回顾显示，胸腺瘤发生中枢神经系统转移的病例不到10例。其中只有两例具有与本病例相似的临床病理特征。
