Beltrán S, Varea V, Vilar P, Cusí V, Vila J, Farré C
An Esp Pediatr. 1978 May;11(5):383-400.
The gastric mucosa in 113 children from 6 months to 14 years old was studied from a histopathological point of view. Samples were obtained by means of a multiple biopsy technique during an endoscopic examination. The patients were divided into two groups. Group A was composed of 97 children with abdominal pain of an unknown etiology. Group B was formed of 16 patients with extragastric pathology in whom it was possible to take biopsies during an endoscopic exam. All of the biopsies were normal, and therefore were used as the control group. 49 patients from group A were histologically normal. In the other 48, lesions of chronic gastritis ranging in severity, were found in the antrum and/or in the gastric body. An analysis of the histopathological findings, and of the lesional sings of activity was done in accordance with Whitehead's criteria. Macroscopic objective features observed during the endoscopical examinations, were also evaluated and compared with the existence or nonexistence of chronic gastritis lesions. In the gastric body, the existence of endoscopic features such as enlarged folds, erosions or friable mucosa, were found to be coincident with the presence of histologic lesions of chronic gastritis. The same relationship was found in the antrum between the granular mucosa and/or irregular coloration and the lesions of chronic gastritis. In the same time, acid secretion studies (BAO, MAO and PAO) from 40 patients from group A were done using pentagastrin as a stimulant. It was demonstrated that both basal acid output and maximal acid were significantly lowered in cases of advanced lesions of chronic gastritis located in the gastric body. Finally the importance of this entity is emphasized in the gastrointestinal pathology in children.
从组织病理学角度对113名6个月至14岁儿童的胃黏膜进行了研究。在内镜检查期间，通过多次活检技术获取样本。患者被分为两组。A组由97名病因不明的腹痛儿童组成。B组由16名患有胃外病变的患者组成，这些患者在内镜检查时可以进行活检。所有活检均正常，因此用作对照组。A组49名患者组织学正常。在另外48名患者中，在胃窦和/或胃体发现了严重程度不同的慢性胃炎病变。根据怀特黑德标准对组织病理学发现和活动性病变迹象进行了分析。还对内镜检查期间观察到的宏观客观特征进行了评估，并与慢性胃炎病变的存在与否进行了比较。在胃体，发现内镜特征如皱襞增大、糜烂或黏膜易碎与慢性胃炎的组织学病变同时存在。在胃窦，颗粒状黏膜和/或颜色不规则与慢性胃炎病变之间也发现了相同的关系。同时，使用五肽胃泌素作为刺激剂对A组40名患者进行了胃酸分泌研究（基础胃酸分泌量、最大胃酸分泌量和高峰胃酸分泌量）。结果表明，位于胃体的晚期慢性胃炎病变患者的基础胃酸分泌量和最大胃酸分泌量均显著降低。最后强调了这一实体在儿童胃肠病理学中的重要性。
