Morita T, Morita R, Takagi S, Shimoyama N, Nagai K
Acta Pathol Jpn. 1981 Jan;31(1):161-6.
A case of acute lymphoblastic leukemia with a giant splenomegaly in an 8-year-old boy was investigated by immunological, cytochemical and electronmicroscopical techniques. Bone marrow and peripheral blood were largely replaced by large blast cells with a nonconvoluted nucleus. Cytochemically, most of the blast cells showed strong focal acid phosphatase activity. In the surface marker studies, these blast cells formed EAC rosettes but not E rosettes, while they showed positive reactivity with anti-T lymphocyte serum but not with anti-B lymphocyte serum. This membrane phenotype E-, C3R+, T+, B- suggested that leukemic blast cells in this patient presumably originated from precursor T cells.
一名8岁男孩患急性淋巴细胞白血病并伴有巨大脾脏肿大，采用免疫、细胞化学和电子显微镜技术进行了研究。骨髓和外周血大部分被具有非卷曲核的大原始细胞取代。细胞化学分析显示，大多数原始细胞呈现强烈的局灶性酸性磷酸酶活性。在表面标志物研究中，这些原始细胞形成EAC玫瑰花结但不形成E玫瑰花结，同时它们与抗T淋巴细胞血清呈阳性反应，而与抗B淋巴细胞血清无反应。这种膜表型E-、C3R+、T+、B-表明该患者的白血病原始细胞可能起源于T细胞前体。
