Sistonen P, Nevanlinna H R, Virtaranta-Knowles K, Pirkola A, Leikola J, Kekomäki R, Gavin J, Tippett P
Vox Sang. 1981 May;40(5):352-7. doi: 10.1111/j.1423-0410.1981.tb00720.x.
A previously unrecognized blood group antigen is described. The antigen was shown to be different from many rare blood group antigens, to be inherited as an autosomal dominant character and not to be closely linked to the established blood group systems nor to several other polymorphic markers of blood. The antigen is well developed at birth. About 5% of Finns have this antigen. In contrast only 1 donor in 502 Swiss blood donors and 2 unrelated donors in 395 Swedish blood donors were found to be positive for the antigen. The antigen is provisionally called Nea and the respective antibody anti-Nea. At least three Na(a+) blood units were given to a patient on different occasions before anti-Nea was detected in compatibility tests. Since the discovery of the first anti-Nea, three additional examples of this antibody have been identified in serum from multitransfused patients. Anti-Nea is capable of shortening the in vivo survival of transfused incompatible Ne(a+) cells.
本文描述了一种此前未被识别的血型抗原。该抗原与许多罕见血型抗原不同，呈常染色体显性遗传，与已确定的血型系统以及其他几种血液多态性标记物均无紧密关联。该抗原在出生时就已充分发育。约5%的芬兰人拥有这种抗原。相比之下，在502名瑞士献血者中仅发现1名献血者呈阳性，在395名瑞典献血者中也仅发现2名无关献血者呈阳性。该抗原暂称为Nea，相应抗体称为抗Nea。在相容性检测中检测到抗Nea之前，至少有三个Ne(a+)血单位在不同时间输给了一名患者。自发现首例抗Nea以来，在多次输血患者的血清中又鉴定出另外三例该抗体。抗Nea能够缩短输入的不相容Ne(a+)细胞在体内的存活时间。
