Sistonen P, Nevanlinna H R, Virtaranta-Knowles K, Tuominen I, Pirkola A, Green C A, Tippett P
Vox Sang. 1987;52(1-2):111-4. doi: 10.1111/j.1423-0410.1987.tb03003.x.
A previously unrecognized infrequent blood group antigen WES occurs with a frequency of 0.56% in the Finnish population, but has an ethnically restricted distribution. Apart from Finns it was found only in 2 donors, most likely of African origin, among 4,655 people tested who represented many different ethnic groups. WES is shown to be a dominant autosomally inherited character different from previously published infrequent antigens. The data allow exclusion from almost all established blood group systems. The WES antigen is destroyed by enzymes alpha-chymotrypsin and pronase. It is also present in plasma of WES+ individuals. Evidence suggests that the soluble form of the antigen is a high molecular weight protein constituent of plasma. Unlike many other antigens present on red cells as well as in plasma, the WES antigen is well developed on red cells of neonates and can also be found in cord serum.
一种此前未被识别的罕见血型抗原WES在芬兰人群中的出现频率为0.56%，但其分布具有种族局限性。除芬兰人外，在接受检测的4655名代表许多不同种族的人中，仅在另外2名供者（很可能来自非洲）身上发现了该抗原。研究表明，WES是一种显性常染色体遗传性状，与此前公布的罕见抗原不同。这些数据几乎可以将其排除在所有已确立的血型系统之外。WES抗原可被α-糜蛋白酶和链霉蛋白酶破坏。它也存在于WES阳性个体的血浆中。有证据表明，该抗原的可溶性形式是血浆中的一种高分子量蛋白质成分。与许多其他存在于红细胞以及血浆中的抗原不同，WES抗原在新生儿的红细胞上发育良好，并且在脐带血清中也能找到。
