Thivolet J, Robart S, Vignon E
Ann Dermatol Venereol. 1981;108(2):131-7.
Combined oral retinoid (RO 10.9359) and PUVA therapy were given to 107 patients with psoriasis, 9 of whom had psoriatic arthropathy. Treatment was started with the retinoid at a dose of 1 mg/kg day and PUVA therapy added after 2 weeks. No other treatment was given. In 100 patients the combined therapy achieved clearing of the lesions, including scalp lesions, in a shorter time and with less total joules/cm2 than a group treated by PUVA alone. The remaining 7 patients were not responding to PUVA alone but achieved clearing when the retinoid was added. Five patients out of 9 with psoriatic arthropathy responded to the combined therapy. Predictable mild side-effects from the retinoid were encountered. The teratogenic risk of retinoid therapy is emphasized. The value of combined retinoid-PUVA therapy in psoriasis is discussed.
对107例银屑病患者给予联合口服维甲酸（RO 10.9359）及补骨脂素紫外线A（PUVA）治疗，其中9例患有银屑病关节炎。治疗从维甲酸开始，剂量为1毫克/千克/天，2周后加用PUVA治疗。未给予其他治疗。与单独接受PUVA治疗的一组相比，100例患者采用联合治疗在更短时间内实现了包括头皮病变在内的皮损清除，且每平方厘米所需的总焦耳数更少。其余7例患者单独使用PUVA治疗无效，但加用维甲酸后实现了皮损清除。9例银屑病关节炎患者中有5例对联合治疗有反应。出现了维甲酸可预见的轻度副作用。强调了维甲酸治疗的致畸风险。讨论了维甲酸-PUVA联合治疗在银屑病中的价值。
