Roberts A J, Sanders J H, Moran J M, Kaplan K J, Lichtenthal P R, Spies S M, Michaelis L L
Ann Thorac Surg. 1981 Jun;31(6):502-11. doi: 10.1016/s0003-4975(10)61339-2.
The quest for the ideal method of myocardial preservation during coronary artery bypass graft (CABG) surgery continues at a rapid pace. Nevertheless, in the present clinical practice of cardiac surgery, the choice is chiefly between hypothermic intermittent ischemic arrest and hypothermic potassium cardioplegia. This study applies newer technics in radionuclear cardiology, as well as more conventional enzymatic, electrocardiographic, and hemodynamic determinations, to the evaluation of the effectiveness of the previously mentioned modes of myocardial protection. Serial assessments are made preoperatively as well as during the first ten days postoperatively. We find that the perioperative incidence of myocardial damage and changes in left ventricular performance are almost identical using either method in patients with relatively normal preoperative left ventricular performance who do not have severe preoperative refractory ischemia or necrosis.
在冠状动脉旁路移植术(CABG)手术期间,对理想的心肌保护方法的探索仍在快速进行。然而,在目前心脏外科的临床实践中,主要的选择是低温间歇性缺血停搏和低温钾诱导心脏停搏。本研究将放射性核素心脏病学中的新技术以及更传统的酶学、心电图和血流动力学测定方法应用于评估上述心肌保护模式的有效性。在术前以及术后头十天进行连续评估。我们发现,对于术前左心室功能相对正常、没有严重术前难治性缺血或坏死的患者,使用这两种方法中的任何一种,心肌损伤的围手术期发生率和左心室功能的变化几乎相同。