Herman J H, Nutman T B, Nozoe M, Mowery C S, Dennis M V
Arthritis Rheum. 1981 Jun;24(6):824-34. doi: 10.1002/art.1780240610.
Spontaneously released and T cell mitogen augmented lymphokine produced by human mononuclear cells has been shown to induce a concentration dependent reversible suppression of chondrocyte glycosaminoglycan and protein synthesis without significantly enhancing chondrocyte catabolic activity. The modulatory factor(s) is of T cell origin and is trypsin, pronase, and heat sensitive. Prostaglandin inhibitors failed to influence factor formation or activity. Although eluting from Sephadex G-100 over a wide range, peak activity had an approximate molecular weight of 53,000 and appeared distinct from recognized forms of lymphotoxin.
人单核细胞自发释放以及T细胞有丝分裂原增强产生的淋巴因子已被证明可诱导软骨细胞糖胺聚糖和蛋白质合成呈浓度依赖性可逆抑制，而不会显著增强软骨细胞的分解代谢活性。调节因子来源于T细胞，对胰蛋白酶、链霉蛋白酶和热敏感。前列腺素抑制剂未能影响因子的形成或活性。尽管在Sephadex G - 100上有很宽的洗脱范围，但峰值活性的分子量约为53,000，且与公认的淋巴毒素形式不同。
