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1
Carrageenin-induced arthritis. VI. Alterations in amino acid transport by articular cartilage in acute inflammatory arthritis.角叉菜胶诱导的关节炎。VI. 急性炎症性关节炎中关节软骨氨基酸转运的改变。
Ann Rheum Dis. 1985 Jul;44(7):477-84. doi: 10.1136/ard.44.7.477.
2
Carrageenin-induced arthritis. II. Effect of intraarticular injection of carrageenin on the synthesis of proteoglycan in articular cartilage.角叉菜胶诱导的关节炎。II. 关节内注射角叉菜胶对关节软骨中蛋白聚糖合成的影响。
Arthritis Rheum. 1976 Sep-Oct;19(5):918-22. doi: 10.1002/art.1780190513.
3
Carrageenin-induced arthritis. I. The effect of intraarticular carrageenin on the chemical composition of articular cartilage.角叉菜胶诱导的关节炎。I. 关节内注射角叉菜胶对关节软骨化学成分的影响。
Arthritis Rheum. 1976 Jul-Aug;19(4):769-76. doi: 10.1002/1529-0131(197607/08)19:4<769::aid-art1780190419>3.0.co;2-v.
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Transport of neutral amino acids by adult articular cartilage.成年关节软骨对中性氨基酸的转运
Connect Tissue Res. 1983;11(4):321-30. doi: 10.3109/03008208309004864.
5
Carrageenin-induced arthritis: V. A morphologic study of the development of inflammation in acute arthritis.角叉菜胶诱导的关节炎：V. 急性关节炎炎症发展的形态学研究
Semin Arthritis Rheum. 1983 Nov;13(2):160-8. doi: 10.1016/0049-0172(83)90002-1.
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Oxidation of articular cartilage glyceraldehyde-3-phosphate dehydrogenase (G3PDH) occurs in vivo during carrageenin-induced arthritis.在角叉菜胶诱导的关节炎中，体内会发生关节软骨甘油醛-3-磷酸脱氢酶（G3PDH）的氧化。
Agents Actions. 1991 Mar;32(3-4):299-304. doi: 10.1007/BF01980890.
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Intra-articular injections and articular cartilage metabolism. An experimental study in rabbits.关节内注射与关节软骨代谢。一项在兔子身上的实验研究。
Arch Orthop Trauma Surg. 1992;111(4):237-41. doi: 10.1007/BF00571486.
8
Carrageenin-induced arthritis. IV. Rate changes in cartilage matrix proteoglycan synthesis.角叉菜胶诱导的关节炎。IV. 软骨基质蛋白聚糖合成的速率变化。
Arthritis Rheum. 1977 Apr;20(3):834-40. doi: 10.1002/art.1780200313.
9
[Studies on the biochemical alterations of cartilage proteoglycan in antigen induced arthritis of rabbit (author's transl)].兔抗原诱导性关节炎中软骨蛋白聚糖生化改变的研究（作者译）
Nihon Seikeigeka Gakkai Zasshi. 1981 Aug;55(8):755-67.
10
Concentration and degradation of hyaluronic acid in knee synovial fluid from carrageenin-induced rabbit arthritis.角叉菜胶诱导的兔关节炎模型膝关节滑液中透明质酸的浓度及降解情况
Chem Pharm Bull (Tokyo). 1990 Jul;38(7):1953-6. doi: 10.1248/cpb.38.1953.

本文引用的文献

1
DISTINCT MEDIATING SYSTEMS FOR THE TRANSPORT OF NEUTRAL AMINO ACIDS BY THE EHRLICH CELL.艾氏细胞转运中性氨基酸的不同介导系统。
J Biol Chem. 1963 Nov;238:3686-99.
2
The transport of neutral amino acids in cultured human fibroblasts.培养的人成纤维细胞中中性氨基酸的转运
J Biol Chem. 1980 Feb 10;255(3):929-36.
3
The A, ASC, and L systems for the transport of amino acids in Chinese hamster ovary cells (CHO-K1).中国仓鼠卵巢细胞（CHO-K1）中用于氨基酸转运的A、ASC和L系统
J Biol Chem. 1981 Oct 25;256(20):10259-66.
4
Evidence for polymorphonuclear-leucocyte-derived proteinases in arthritic cartilage.关节炎性软骨中多形核白细胞衍生蛋白酶的证据。
Biochem J. 1981 Jan 1;193(1):193-202. doi: 10.1042/bj1930193.
5
Lymphokine-mediated suppression of chondrocyte glycosaminoglycan and protein synthesis.淋巴因子介导的软骨细胞糖胺聚糖和蛋白质合成抑制。
Arthritis Rheum. 1981 Jun;24(6):824-34. doi: 10.1002/art.1780240610.
6
Effects of insulin and multiplication-stimulating activity on proteoglycan biosynthesis in chondrocytes from the Swarm rat chondrosarcoma.胰岛素和促增殖活性对斯旺大鼠软骨肉瘤软骨细胞中蛋白聚糖生物合成的影响。
J Biol Chem. 1981 Feb 25;256(4):2045-52.
7
Carrageenin-induced arthritis: V. A morphologic study of the development of inflammation in acute arthritis.角叉菜胶诱导的关节炎：V. 急性关节炎炎症发展的形态学研究
Semin Arthritis Rheum. 1983 Nov;13(2):160-8. doi: 10.1016/0049-0172(83)90002-1.
8
Changes in proteoglycan biosynthesis following leukocyte elastase treatment of bovine articular cartilage in culture.培养的牛关节软骨经白细胞弹性蛋白酶处理后蛋白聚糖生物合成的变化。
Arthritis Rheum. 1984 Aug;27(8):905-12. doi: 10.1002/art.1780270810.
9
Transport of neutral amino acids by adult articular cartilage.成年关节软骨对中性氨基酸的转运
Connect Tissue Res. 1983;11(4):321-30. doi: 10.3109/03008208309004864.
10
A distinct Na+-requiring transport system for alanine, serine, cysteine, and similar amino acids.一种独特的、需要钠离子的丙氨酸、丝氨酸、半胱氨酸及类似氨基酸的转运系统。
J Biol Chem. 1967 Nov 25;242(22):5237-46.

角叉菜胶诱导的关节炎。VI. 急性炎症性关节炎中关节软骨氨基酸转运的改变。

Carrageenin-induced arthritis. VI. Alterations in amino acid transport by articular cartilage in acute inflammatory arthritis.

作者信息

Byers S, Handley C J, Lowther D A, Sriratana A

出版信息

Ann Rheum Dis. 1985 Jul;44(7):477-84. doi: 10.1136/ard.44.7.477.

DOI:10.1136/ard.44.7.477
PMID:4026408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1001679/
Abstract

The mechanism of transport of alanine and aminoisobutyric acid into chondrocytes in rabbit articular cartilage was shown to be mediated by transport systems similar to that described for other eukaryotic cells namely the A, ASC, and L systems. Three days after the initiation of an acute inflammatory arthritis by the intra-articular injection of carrageenin into one knee joint the rate of transport of both these amino acids was decreased. Although all three transport systems were depressed, it appeared that the A and ASC systems were partially susceptible to damage by the induced inflammation. The rate of amino acid transport by the affected cartilage had recovered by 28 days after carrageenin treatment. This depression in amino acid transport is discussed in relation to a decrease in general metabolic processes in chondrocytes as a consequence of inflammation.

摘要

研究表明，丙氨酸和氨基异丁酸进入兔关节软骨细胞的转运机制是由与其他真核细胞中所描述的类似转运系统介导的，即A、ASC和L系统。通过向一个膝关节内注射角叉菜胶引发急性炎症性关节炎三天后，这两种氨基酸的转运速率均降低。尽管所有三种转运系统均受到抑制，但似乎A和ASC系统部分易受诱导炎症的损伤。角叉菜胶处理后28天，受影响软骨的氨基酸转运速率已恢复。本文讨论了氨基酸转运的这种抑制与炎症导致软骨细胞一般代谢过程减少之间的关系。