Ginsberg J, Hamblet J, Menefee M
Ann Ophthalmol. 1978 Aug;10(8):1021-8.
A 61-year-old white woman with terminal myotonic dystrophy exhibited advanced peripheral and central retinopathy. Retinal lesions were characterized by hyperpigmentation, common, though nonspecific, in myotonic dystrophy. They resemble both heredo (tapetoretinal) and idiopathic involutional degenerations but rarely cause severe visual impairment. Neither the type nor degree of retinopathy appears to correlate with other ocular features or with the stage of the underlying disease. Our histologic observations confirm and extend those previously described. Electron microscopy suggests a primary disorder of mitochondria which may also affect smooth muscle and the myocardium.
一名患有晚期强直性肌营养不良的61岁白人女性出现了严重的周边和中央视网膜病变。视网膜病变的特征是色素沉着，这在强直性肌营养不良中很常见，但不具有特异性。它们类似于遗传性（毯层视网膜）和特发性退行性变，但很少导致严重的视力损害。视网膜病变的类型和程度似乎与其他眼部特征或潜在疾病的阶段均无关联。我们的组织学观察结果证实并扩展了先前描述的内容。电子显微镜检查提示线粒体存在原发性病变，这可能也会影响平滑肌和心肌。
